Human Recombinant NRP2 protein, His Tag (V2LY-0526-LY5775)

Name: Human Recombinant NRP2 protein, His Tag
SKU: V2LY-0526-LY5775
Rating: 5 (1 reviews)

See all NRP2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant NRP2 protein, His Tag consist of Amino Acid: 1-855 and predicts a molecular mass of 95 kDa.

Molecule Mass

95 kDa

Verified

HPLC

Sequence

Amino Acid: 1-855

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

neuropilin 2

Function

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.

Biological Process

Angiogenesis1 PublicationNAS:UniProtKB
Axon extension involved in axon guidanceISS:BHF-UCL
Axon guidanceManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion1 PublicationNAS:UniProtKB
Cellular response to leukemia inhibitory factorIEA:Ensembl
Dorsal root ganglion morphogenesisIEA:Ensembl
Facial nerve structural organizationIEA:Ensembl
Facioacoustic ganglion developmentIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Negative chemotaxisIEA:Ensembl
Nerve developmentISS:BHF-UCL
Neural crest cell migration involved in autonomic nervous system developmentIEA:Ensembl
Outflow tract septum morphogenesisISS:BHF-UCL
Positive regulation of endothelial cell migrationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of postsynapse organizationIEA:Ensembl
Semaphorin-plexin signaling pathway involved in neuron projection guidanceISS:BHF-UCL
Sensory neuron axon guidanceIEA:Ensembl
Sympathetic ganglion developmentISS:BHF-UCL
Sympathetic neuron projection extensionISS:BHF-UCL
Sympathetic neuron projection guidanceISS:BHF-UCL
Trigeminal ganglion developmentIEA:Ensembl
Ventral trunk neural crest cell migrationIEA:Ensembl
Vestibulocochlear nerve structural organizationIEA:Ensembl

Cellular Location

Membrane
Isoform s9
Secreted

Topology

Extracellular: 21-864
Helical: 865-889
Cytoplasmic: 890-931

Immormino, R. M., Jania, C. M., Tilley, S. L., & Moran, T. P. (2022). Neuropilin‐2 regulates airway inflammation in a neutrophilic asthma model. Immunity, Inflammation and Disease, 10(3), e575.

Wang, J., Li, J., Yin, L., Pu, T., Wei, J., Karthikeyan, V., ... & Wu, B. J. (2022). Neuropilin-2 promotes lineage plasticity and progression to neuroendocrine prostate cancer. Oncogene, 41(37), 4307-4317.

Lungulescu, C., Ghimpau, V., Gheonea, D. I., Sur, D., & Lungulescu, C. V. (2022). The Role of neuropilin-2 in the epithelial to mesenchymal transition of colorectal cancer: A systematic review. Biomedicines, 10(1), 172.

Islam, R., Mishra, J., Bodas, S., Bhattacharya, S., Batra, S. K., Dutta, S., & Datta, K. (2022). Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance. Cancer and Metastasis Reviews, 41(3), 771-787.

Dumond, A., Brachet, E., Durivault, J., Vial, V., Puszko, A. K., Lepelletier, Y., ... & Pagès, G. (2021). Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. Journal of experimental & clinical cancer research, 40, 1-18.

Dumond, A., & Pagès, G. (2021). Relevance of neuropilin 1 and neuropilin 2 targeting for cancer treatment. Journal of Cancer Immunology, 3(2), 111-114.

Lee, G., Kang, Y. E., Oh, C., Liu, L., Jin, Y., Lim, M. A., ... & Koo, B. S. (2020). Neuropilin-2 promotes growth and progression of papillary thyroid cancer cells. Auris Nasus Larynx, 47(5), 870-880.

Borkowetz, A., Froehner, M., Rauner, M., Conrad, S., Erdmann, K., Mayr, T., ... & Muders, M. H. (2020). Neuropilin‐2 is an independent prognostic factor for shorter cancer‐specific survival in patients with acinar adenocarcinoma of the prostate. International journal of cancer, 146(9), 2619-2627.

Harman, J. L., Sayers, J., Chapman, C., & Pellet-Many, C. (2020). Emerging roles for neuropilin-2 in cardiovascular disease. International Journal of Molecular Sciences, 21(14), 5154.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant NRP2 protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant NRP2 protein, hFc Tag (CAT#: V2LY-0526-LY5774)

Mouse Recombinant NRP2 protein, His Tag (CAT#: V2LY-0526-LY8701)

Related Products

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1033) (CAT#: CBMAB-N0539-WJ)

Rabbit Anti-NRP2 Recombinant Antibody (D39A5) (CAT#: CBMAB-N3625-WJ)

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1032) (CAT#: CBMAB-N0538-WJ)

Mouse Anti-NRP2 Recombinant Antibody (3B8) (CAT#: CBMAB-N3624-WJ)

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1556) (CAT#: CBMAB-N3622-WJ)

Mouse Anti-NRP2 Recombinant Antibody (2A4H7C11) (CAT#: CBMAB-N3623-WJ)

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1031) (CAT#: CBMAB-N0537-WJ)

Mouse Recombinant NRP2 protein, His Tag (CAT#: V2LY-0526-LY8701)

Mouse Anti-NRP2 Recombinant Antibody (M391) (CAT#: CBMAB-N3626-WJ)

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1555) (CAT#: CBMAB-N3621-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry