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NRP2

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Full Name
neuropilin 2
Function
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells.
Biological Process
Angiogenesis1 PublicationNAS:UniProtKB
Axon extension involved in axon guidanceISS:BHF-UCL
Axon guidanceManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion1 PublicationNAS:UniProtKB
Cellular response to leukemia inhibitory factorIEA:Ensembl
Dorsal root ganglion morphogenesisIEA:Ensembl
Facial nerve structural organizationIEA:Ensembl
Facioacoustic ganglion developmentIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Negative chemotaxisIEA:Ensembl
Nerve developmentISS:BHF-UCL
Neural crest cell migration involved in autonomic nervous system developmentIEA:Ensembl
Outflow tract septum morphogenesisISS:BHF-UCL
Positive regulation of endothelial cell migrationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of postsynapse organizationIEA:Ensembl
Semaphorin-plexin signaling pathway involved in neuron projection guidanceISS:BHF-UCL
Sensory neuron axon guidanceIEA:Ensembl
Sympathetic ganglion developmentISS:BHF-UCL
Sympathetic neuron projection extensionISS:BHF-UCL
Sympathetic neuron projection guidanceISS:BHF-UCL
Trigeminal ganglion developmentIEA:Ensembl
Ventral trunk neural crest cell migrationIEA:Ensembl
Vestibulocochlear nerve structural organizationIEA:Ensembl
Cellular Location
Membrane
Isoform s9
Secreted
Topology
Extracellular: 21-864
Helical: 865-889
Cytoplasmic: 890-931
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Anti-NRP2 antibodies

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Rabbit Anti-NRP2 Recombinant Antibody (D39A5) (CBMAB-N3625-WJ)

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Target: NRP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: D39A5
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (M391) (CBMAB-N3626-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: M391
Application*: WB, E
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (3B8) (CBMAB-N3624-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B8
Application*: E, WB
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (2A4H7C11) (CBMAB-N3623-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A4H7C11
Application*: E, ED
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1556) (CBMAB-N3622-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1556
Application*: WB
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1555) (CBMAB-N3621-WJ)

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Target: NRP2
Host: Mouse
Specificity: Human
Clone: CBWJN-1555
Application*: EC
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1033) (CBMAB-N0539-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1033
Application*: F, MC
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1032) (CBMAB-N0538-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJN-1032
Application*: WB, F, MC
Datasheet SDS

Mouse Anti-NRP2 Recombinant Antibody (CBWJN-1031) (CBMAB-N0537-WJ)

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Target: NRP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1031
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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