Human Recombinant NSD3 protein, GST Tag (V2LY-0526-LY7670)

Name: Human Recombinant NSD3 protein, GST Tag
SKU: V2LY-0526-LY7670
Rating: 5 (1 reviews)

See all NSD3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant NSD3 protein, GST Tag consist of Amino Acid: 1038-end and predicts a molecular mass of 72 kDa.

Molecule Mass

72 kDa

Sequence

Amino Acid: 1038-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Nuclear Receptor Binding SET Domain Protein 3

Function

Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K36 trimethylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Chromosome

Involvement in disease

Defects in NSD3 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.
A chromosomal aberration involving NSD3 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

Xiong, Q., Zhou, Y., Zhang, S., Zhang, Y., Xu, Y., Yang, Y., ... & Zhu, Q. (2023). NSD3, a member of nuclear receptor‐binding SET domain family, is a potential prognostic biomarker for pancreatic cancer. Cancer Medicine, 12(9), 10961-10978.

Kim, S., Hwang, I., Kim, S. H., Chung, H. W., Ji, M. J., Moon, S., ... & Hur, W. (2023). Identification of novel class inhibitors of NSD3 methyltransferase showing a unique, bivalent binding mode in the SET domain. Chemical Biology & Drug Design, 102(3), 500-513.

Topchu, I., Pangeni, R. P., Bychkov, I., Miller, S. A., Izumchenko, E., Yu, J., ... & Boumber, Y. (2022). The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors. Cellular and Molecular Life Sciences, 79(6), 285.

Sun, Y., Xie, J., Cai, S., Wang, Q., Feng, Z., Li, Y., ... & Ye, Z. (2021). Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth. Cell Death & Disease, 12(10), 913.

Rathert, P. (2021). Structure, activity and function of the NSD3 protein lysine methyltransferase. Life, 11(8), 726.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant NSD3 protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-NSD3 Recombinant Antibody (D4N9N) (CAT#: CBMAB-CP3016-LY)

Mouse Anti-NSD3 Recombinant Antibody (1F11) (CAT#: CBMAB-N0006-WJ)

Mouse Anti-NSD3 Recombinant Antibody (8G3) (CAT#: CBMAB-N0005-WJ)

Mouse Anti-NSD3 Recombinant Antibody (CBWJN-0705) (CAT#: CBMAB-N3652-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry