NSD3

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]

Full Name

Nuclear Receptor Binding SET Domain Protein 3

Function

Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K36 trimethylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Chromosome

Involvement in disease

Defects in NSD3 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.
A chromosomal aberration involving NSD3 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

Anti-NSD3 antibodies

Mouse Anti-NSD3 Recombinant Antibody (1F11) (CBMAB-N0006-WJ)

Datasheet

SDS

Target: NSD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F11

Application*: WB

Mouse Anti-NSD3 Recombinant Antibody (8G3) (CBMAB-N0005-WJ)

Datasheet

SDS

Target: NSD3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 8G3

Application*: E, WB

Rabbit Anti-NSD3 Recombinant Antibody (D4N9N) (CBMAB-CP3016-LY)

Datasheet

SDS

Target: NSD3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D4N9N

Application*: WB, IP, P, F

Mouse Anti-NSD3 Recombinant Antibody (CBWJN-0705) (CBMAB-N3652-WJ)

Datasheet

SDS

Target: NSD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBWJN-0705

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)