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NSD3

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]

Full Name

Nuclear Receptor Binding SET Domain Protein 3

Function

Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Histone methylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of histone H3-K36 trimethylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Chromosome

Involvement in disease

Defects in NSD3 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.
A chromosomal aberration involving NSD3 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.

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Anti-NSD3 antibodies

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Human Recombinant NSD3 protein, GST Tag (V2LY-0526-LY7670)

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Target: NSD3

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1038-end

Tag: GST Tag

Rabbit Anti-NSD3 Recombinant Antibody (D4N9N) (CBMAB-CP3016-LY)

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Target: NSD3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D4N9N

Application*: WB, IP, P, F

Mouse Anti-NSD3 Recombinant Antibody (CBWJN-0705) (CBMAB-N3652-WJ)

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Target: NSD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: CBWJN-0705

Application*: WB

Mouse Anti-NSD3 Recombinant Antibody (1F11) (CBMAB-N0006-WJ)

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Target: NSD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F11

Application*: WB

Mouse Anti-NSD3 Recombinant Antibody (8G3) (CBMAB-N0005-WJ)

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Target: NSD3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 8G3

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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