Human Recombinant TRIB3 protein, GST Tag (V2LY-0526-LY7375)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988).
May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988).
Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity).
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity).
May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity).
Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262).
Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019).
Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230).
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of fat cell differentiation Source:BHF-UCLBy Similarity
Biological Process negative regulation of fatty acid biosynthetic process Source:BHF-UCLBy Similarity
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process positive regulation of protein binding Source:BHF-UCLBy Similarity
Biological Process positive regulation of ubiquitin-protein transferase activity Source:BHF-UCLBy Similarity
Biological Process protein phosphorylation Source:InterPro
Biological Process regulation of autophagy Source:UniProtKB
Biological Process regulation of glucose transmembrane transport Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stress Source:UniProtKB1 Publication
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant TRIB3 protein, GST Tag-1 (CAT#: V2LY-0526-LY7376)
Antibody Pairs
TRIB3 Matched Antibody Pair (1272) (CAT#: APMAB-1272LY)
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Human Recombinant TRIB3 protein, GST Tag-1 (CAT#: V2LY-0526-LY7376)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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