TRIB3

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

TRIB3 Gene(Protein Coding) Tribbles Pseudokinase 3

Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15781252, PubMed:15775988).
Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988).
May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988).
Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity).
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity).
May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity).
Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262).
Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019).
Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230).

Biological Process cellular response to insulin stimulus Source:BHF-UCLBy Similarity
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of fat cell differentiation Source:BHF-UCLBy Similarity
Biological Process negative regulation of fatty acid biosynthetic process Source:BHF-UCLBy Similarity
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process positive regulation of protein binding Source:BHF-UCLBy Similarity
Biological Process positive regulation of ubiquitin-protein transferase activity Source:BHF-UCLBy Similarity
Biological Process protein phosphorylation Source:InterPro
Biological Process regulation of autophagy Source:UniProtKB
Biological Process regulation of glucose transmembrane transport Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB1 Publication
Biological Process response to endoplasmic reticulum stress Source:UniProtKB1 Publication

Nucleus