Human Recombinant USP16, Active protein, GST Tag (V2LY-0526-LY7563)

Name: Human Recombinant USP16, Active protein, GST Tag
SKU: V2LY-0526-LY7563
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant USP16, Active protein, GST Tag consist of Amino Acid: 187-end and predicts a molecular mass of 110 kDa.

Molecule Mass

110 kDa

Sequence

Amino Acid: 187-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

USP16

Function

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Biological Process

Biological Process cell division Source:UniProtKB-KW
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process histone deubiquitination Source:UniProtKB1 Publication
Biological Process histone H2A K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process mitotic cell cycle Source:UniProtKB1 Publication
Biological Process mitotic nuclear division Source:UniProtKB-UniRule
Biological Process monoubiquitinated histone H2A deubiquitination Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process positive regulation of translational elongation Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:Reactome
Biological Process protein homotetramerization Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:InterPro
Biological Process regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.

PTM

Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-USP16 (aa 137-466) Recombinant Antibody (1B4) (CAT#: CBMAB-U0020-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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