Human Recombinant VRK1 protein (V2LY-0526-LY7646)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation (PubMed:19103756).
Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 (PubMed:10951572).
Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429).
Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (PubMed:16495336).
Phosphorylates ATF2 which activates its transcriptional activity (PubMed:15105425).
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process Golgi disassembly Source:UniProtKB1 Publication
Biological Process mitotic nuclear membrane disassembly Source:Reactome
Biological Process peptidyl-serine phosphorylation Source:GO_Central1 Publication
Biological Process positive regulation of protein localization to chromatin Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process protein phosphorylation Source:ProtInc1 Publication
Biological Process signal transduction Source:GO_Central1 Publication
Cytoplasm
Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
A disorder characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and spinal cord anterior horn cells degeneration resembling infantile spinal muscular atrophy. Additional features include muscle hypotonia, congenital contractures and respiratory insufficiency that is evident at birth.
Autophosphorylation does not impair its ability to phosphorylate p53/TP53 (PubMed:11883897).
Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis (PubMed:19103756).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant VRK1, Active protein, GST Tag (CAT#: V2LY-0526-LY7647)
Human Recombinant VRK1 protein, GST Tag (CAT#: V2LY-0526-LY7649)
VRK1 Matched Antibody Pair (1303) (CAT#: APMAB-1303LY)
Antibody Pairs
VRK1 Matched Antibody Pair (1303) (CAT#: APMAB-1303LY)
Related Products
Mouse Anti-VRK1 Recombinant Antibody (2C9) (CAT#: CBMAB-V0056-YC)
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Human Recombinant VRK1 protein, GST Tag (CAT#: V2LY-0526-LY7649)
Human Recombinant VRK1, Active protein, GST Tag (CAT#: V2LY-0526-LY7647)
Mouse Anti-VRK1 Recombinant Antibody (5D1) (CAT#: CBMAB-V0059-YC)
Mouse Anti-VRK1 Recombinant Antibody (1F6) (CAT#: CBMAB-V0061-YC)
Mouse Anti-VRK1 Recombinant Antibody (2E10) (CAT#: CBMAB-V0062-YC)
Mouse Anti-VRK1 Recombinant Antibody (4F9) (CAT#: CBMAB-V0057-YC)
VRK1 Matched Antibody Pair (1303) (CAT#: APMAB-1303LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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