Human TAC1 ELISA Kit (V2LY-0626-LY1741)

tachykinin, precursor 1

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Biological Process antibacterial humoral responseIDA:UniProtKB
Biological Process antifungal humoral responseIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Biological Process cell-cell signalingTAS:ProtInc1 Publication
Biological Process cellular response to nerve growth factor stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionIEA:UniProtKB-KW
Biological Process defense response to Gram-negative bacteriumIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumIDA:UniProtKB
Biological Process detection of abiotic stimulusTAS:ProtInc1 Publication
Biological Process detection of temperature stimulus involved in sensory perception of painIDA:UniProtKB
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process innate immune responseIDA:UniProtKB
Biological Process inseminationTAS:ProtInc1 Publication
Biological Process killing of cells of another organismIDA:UniProtKB
Biological Process negative regulation of neuron deathIGI:ARUK-UCL
Biological Process negative regulation of systemic arterial blood pressureIDA:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB1 Publication
Biological Process positive regulation of flagellated sperm motilityIDA:UniProtKB
Biological Process positive regulation of neuron deathIGI:ARUK-UCL
Biological Process positive regulation of sensory perception of painIDA:UniProtKB
Biological Process regulation of sensory perception of painIDA:UniProtKB
Biological Process response to painIEA:Ensembl
Biological Process response to yeastIDA:UniProtKB
Biological Process sensory perception of painIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayIDA:UniProtKB1 Publication

Secreted

Substance P
The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817).
Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).