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Mouse Anti-5-hmC Recombinant Antibody (V2-7668) (CBMAB-1840CQ)


See all 5-hmC antibodies
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Published Data
Mouse Anti-5-hmC Recombinant Antibody (13612) in Dot blot
Mouse Anti-5-hmC Recombinant Antibody (13612) in Dot blot
5-hmC and 5-mC levels in pancreatic tumor tissues verses adjacent non-tumor tissues were detected by dot blot. ...View More
Wu, J., Li, H., Shi, M., Zhu, Y., Ma, Y., Zhong, Y., ... & Peng, C. (2019). TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells. Journal of Experimental & Clinical Cancer Research, 38, 1-17.
Mouse Anti-5-hmC Recombinant Antibody (13612) in IHC
Mouse Anti-5-hmC Recombinant Antibody (13612) in IHC
A, B Hematoxylin and eosin staining of gastric adenocarcinoma with enteroblastic differentiation (GAED) tissue. Preserved Teneleven translocation 1 (TET1) expression was observed in a case of GAED (C: corresponding to
A). Reduced TET1 expression was observed in a case of GAED (D: corresponding to B). Preserved 5-hydroxymethylcytosine (5-hmc) expression was observed in a case of GAED (E: corresponding to A). Reduced 5-hmc expression
was observed in a case of GAED (F: corresponding to B). Original magnification (A-D), 200× ...View More
Yatagai, N., Saito, T., Akazawa, Y., Hayashi, T., Yanai, Y., Tsuyama, S., ... & Yao, T. (2019). TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation. Virchows Archiv, 474, 315-324.
Mouse Anti-5-hmC Recombinant Antibody (13612) in Dot blot
Mouse Anti-5-hmC Recombinant Antibody (13612) in Dot blot
5hmC levels in MDS-L cells transduced with shSIRT1 #1, shSIRT1 #2 or shCtrl were determined by dot blot. ...View More
Sun, J., He, X., Zhu, Y., Ding, Z., Dong, H., Feng, Y., ... & Li, L. (2018). SIRT1 activation disrupts maintenance of myelodysplastic syndrome stem and progenitor cells by restoring TET2 function. Cell stem cell, 23(3), 355-369.

Summary

Host Animal
Mouse
Clone
V2-7668
Antibody Isotype
IgG2b
Application
IHC-P, IHC, DB, MD

Basic Information

Immunogen
5-HydroxymethylCytosine / 5-hmC.
Host Species
Mouse
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-Hydroxymethylcytosine
Introduction
5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base derived from cytosine. It is potentially important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off.
Alternative Names
5-Hydroxymethylcytosine; 1123-95-1; 4-amino-5-(hydroxymethyl)pyrimidin-2-ol; 4-Amino-5-(hydroxymethyl)-2(1H)-pyrimidinone; 5-HYDROXYMETHYL CYTOSINE; 6-amino-5-(hydroxymethyl)-1H-pyrimidin-2-one; 5-hmc; 5hmc; C5H7N3O2
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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