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Mouse Anti-AKAP7 Recombinant Antibody (V2-611079) (CBMAB-A0232-LY)

The product is antibody recognizes AKAP7. The antibody 1F9 immunoassay techniques such as: WB, ELISA.
See all AKAP7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-611079
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
AKAP7 (AAH16927, 1 a.a. ~ 81 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
A kinase (PRKA) anchor protein 7
Introduction
This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described. Additional variants exist, but their full-length natures have not been determined. [provided by RefSeq]
Entrez Gene ID
9465
UniProt ID
Q9P0M2
Alternative Names
AKAP18
Function
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
Biological Process
Action potential Source: BHF-UCL
Cellular response to cAMP Source: BHF-UCL
Intracellular signal transduction Source: UniProtKB
Ion transport Source: ProtInc
Positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
Positive regulation of potassium ion transmembrane transport Source: BHF-UCL
Protein localization Source: UniProtKB
Regulation of membrane repolarization Source: BHF-UCL
Cellular Location
Isoform Alpha: Lateral cell membrane; Lipid-anchor. Targeted predominantly to the lateral membrane.
Isoform Beta: Apical cell membrane; Lipid-anchor. Targeted predominantly to the apical membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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