Mouse Anti-AKAP7 Recombinant Antibody (V2-611080) (CBMAB-A0233-LY)

Name: Mouse Anti-AKAP7 Recombinant Antibody (V2-611080)
SKU: CBMAB-A0233-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-611080

Application

WB, ELISA

Immunogen

AKAP7 (NP_057461.1, 2 a.a. ~ 115 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

A kinase (PRKA) anchor protein 7

Introduction

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described. Additional variants exist, but their full-length natures have not been determined. [provided by RefSeq]

Entrez Gene ID

9465

UniProt ID

Q9P0M2

Alternative Names

AKAP18

Function

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Biological Process

Action potential Source: BHF-UCL
Cellular response to cAMP Source: BHF-UCL
Intracellular signal transduction Source: UniProtKB
Ion transport Source: ProtInc
Positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
Positive regulation of potassium ion transmembrane transport Source: BHF-UCL
Protein localization Source: UniProtKB
Regulation of membrane repolarization Source: BHF-UCL

Cellular Location

Isoform Alpha: Lateral cell membrane; Lipid-anchor. Targeted predominantly to the lateral membrane.
Isoform Beta: Apical cell membrane; Lipid-anchor. Targeted predominantly to the apical membrane.

O’Connell, G. C., Treadway, M. B., Petrone, A. B., Tennant, C. S., Lucke-Wold, N., Chantler, P. D., & Barr, T. L. (2017). Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption. Scientific reports, 7(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-AKAP7 Recombinant Antibody (V2-611079) (CAT#: CBMAB-A0232-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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