AKAP7

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described. Additional variants exist, but their full-length natures have not been determined. [provided by RefSeq]

Full Name

A kinase (PRKA) anchor protein 7

Function

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Biological Process

Action potential Source: BHF-UCL
Cellular response to cAMP Source: BHF-UCL
Intracellular signal transduction Source: UniProtKB
Ion transport Source: ProtInc
Positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
Positive regulation of potassium ion transmembrane transport Source: BHF-UCL
Protein localization Source: UniProtKB
Regulation of membrane repolarization Source: BHF-UCL

Cellular Location

Isoform Alpha: Lateral cell membrane; Lipid-anchor. Targeted predominantly to the lateral membrane.
Isoform Beta: Apical cell membrane; Lipid-anchor. Targeted predominantly to the apical membrane.