Mouse Anti-GNLY Recombinant Antibody (CBFYH-0405) (V2LY-0226-LY206)

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Basic Information

Host Animal
Mouse
Clone
CBFYH-0405
Application
IF, IP, FC
Immunogen
Human full-length expression plasmid Guranyuraishin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, glycerol
Preservative
None
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
granulysin
Entrez Gene ID
UniProt ID
Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Defense response to fungus Source: UniProtKB-KW
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
PTM
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.

Thakur, P., Sutiwisesak, R., Lu, Y. J., & Behar, S. M. (2022). Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis. Mbio, 13(6), e03020-22.

Milovanović, J., Todorović-Raković, N., Vujasinović, T., Greenman, J., Mandušić, V., & Radulovic, M. (2022). Can granulysin provide prognostic value in primary breast cancer?. Pathology-Research and Practice, 237, 154039.

Drvar, V., Ćurko‑Cofek, B., Karleuša, L., Aralica, M., Rogoznica, M., Kehler, T., ... & Laskarin, G. (2022). Granulysin expression and granulysin‑mediated apoptosis in the peripheral blood of osteoarthritis patients. Biomedical reports, 16(5), 1-10.

Chu, M. T., Wang, C. W., Chang, W. C., Chen, C. B., Chung, W. H., & Hung, S. I. (2021). Granulysin-based lymphocyte activation test for evaluating drug causality in antiepileptics-induced severe cutaneous adverse reactions. Journal of Investigative Dermatology, 141(6), 1461-1472.

Crespo, Â. C., Mulik, S., Dotiwala, F., Ansara, J. A., Santara, S. S., Ingersoll, K., ... & Lieberman, J. (2020). Decidual NK cells transfer granulysin to selectively kill bacteria in trophoblasts. Cell, 182(5), 1125-1139.

Hojo-Souza, N. S., de Azevedo, P. O., de Castro, J. T., Teixeira-Carvalho, A., Lieberman, J., Junqueira, C., & Gazzinelli, R. T. (2020). Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage. PLoS Pathogens, 16(9), e1008840.

Dotiwala, F., & Lieberman, J. (2019). Granulysin: killer lymphocyte safeguard against microbes. Current opinion in immunology, 60, 19-29.

Vičić, M., Kaštelan, M., Tokmadžić, V. S., & Massari, L. P. (2019). Systemic and local increase of granulysin expression in cytotoxic lymphocytes in severe psoriasis. Acta dermato-venereologica, 99(12), 1136-1142.

Lettau, M., Dietz, M., Dohmen, K., Leippe, M., Kabelitz, D., & Janssen, O. (2019). Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation. Molecular immunology, 107, 44-53.

Gulic, T., Laskarin, G., Dominovic, M., Glavan Gacanin, L., Babarović, E., Rubesa, Z., ... & Rukavina, D. (2018). Granulysin‐mediated apoptosis of trophoblasts in blighted ovum and missed abortion. American journal of reproductive immunology, 80(3), e12978.

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For research use only. Not intended for any clinical use.

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