GNLY

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

granulysin

Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Defense response to fungus Source: UniProtKB-KW
Killing of cells of other organism Source: UniProtKB

Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.