GNLY

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Full Name
granulysin
Function
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Defense response to fungus Source: UniProtKB-KW
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted. Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
PTM
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.
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Anti-GNLY antibodies

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Mouse Anti-GNLY Recombinant Antibody (CBLG1-1426) (CBMAB-G4180-LY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-1426
Application*: E, WB
Datasheet SDS

Mouse Anti-GNLY Recombinant Antibody (RF10) (CBMAB-G4179-LY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: RF10
Application*: F
Datasheet SDS

Mouse Anti-GNLY Recombinant Antibody (RB1) (CBMAB-G4178-LY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: RB1
Application*: F
Datasheet SDS

Mouse Anti-GNLY Recombinant Antibody (B-R32) (CBMAB-G4177-LY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-R32
Application*: E (IA)
Datasheet SDS

Mouse Anti-GNLY Recombinant Antibody (B-L38) (CBMAB-G4176-LY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-L38
Application*: E, F
Datasheet SDS

Mouse Anti-GNLY Recombinant Antibody (DH10) (CBMAB-G0580-LY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DH10
Application*: ED
Datasheet SDS

Mouse Anti-GNLY Recombinant Antibody (CBFYH-0405) (CBMAB-H1275-FY)

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Target: GNLY
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0405
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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