Mouse Cel ELISA Kit (V2LY-0626-LY2089)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0053 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
65.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Carboxyl Ester Lipase
Function
Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs) (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499).
Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity).
Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (PubMed:8471055, PubMed:27509211, PubMed:10220579, PubMed:27650499).
Biological Process
Ceramide catabolic process Source: Ensembl
Chemical synaptic transmission Source: GO_Central
Cholesterol catabolic process Source: UniProtKB
Fatty acid catabolic process Source: UniProtKB
Intestinal cholesterol absorption Source: UniProtKB
Intestinal lipid catabolic process Source: UniProtKB
Lipid digestion Source: Reactome
Lipid metabolic process Source: UniProtKB
Modulation of chemical synaptic transmission Source: GO_Central
Neuron cell-cell adhesion Source: GO_Central
Pancreatic juice secretion Source: UniProtKB
Postsynaptic membrane assembly Source: GO_Central
Presynaptic membrane assembly Source: GO_Central
Protein esterification Source: UniProtKB
Synaptic vesicle endocytosis Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Maturity-onset diabetes of the young 8 with exocrine dysfunction (MODY8): The disease is caused by variants affecting the gene represented in this entry. Single base deletions in the VNTR-region, that result in frame shift and protein truncation, have been identified as disease causing variants in MODY8 families (PubMed:16369531). An autosomal dominant form of diabetes characterized by a primary defect in insulin secretion, exocrine pancreatic dysfunction, altered pancreatic morphology, recurrent abdominal pain, and fecal elastase deficiency. Disease onset is at less than 25 years of age.
PTM
N- and O-glycosylated.

Pellegrini, S., Pipitone, G. B., Cospito, A., Manenti, F., Poggi, G., Lombardo, M. T., ... & Piemonti, L. (2021). Generation of β Cells from iPSC of a MODY8 Patient with a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene. The Journal of Clinical Endocrinology & Metabolism, 106(5), e2322-e2333.

Gravdal, A., Xiao, X., Cnop, M., El Jellas, K., Johansson, S., Njølstad, P. R., ... & Fjeld, K. (2021). The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. Journal of Biological Chemistry, 296.

Dalva, M., Lavik, I. K., El Jellas, K., Gravdal, A., Lugea, A., Pandol, S. J., ... & Molven, A. (2020). Pathogenic carboxyl ester lipase (CEL) variants interact with the normal CEL protein in pancreatic cells. Cells, 9(1), 244.

Qiu, Y., Sun, S., Yu, X., Zhou, J., Cai, W., & Qian, L. (2020). Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(6), 158663.

Khatua, B., Trivedi, R. N., Noel, P., Patel, K., Singh, R., de Oliveira, C., ... & Singh, V. P. (2019). Carboxyl ester lipase may not mediate lipotoxic injury during severe acute pancreatitis. The American journal of pathology, 189(6), 1226-1240.

Oracz, G., Kujko, A. A., Fjeld, K., Wertheim-Tysarowska, K., Adamus-Białek, W., Steine, S. J., ... & Rygiel, A. M. (2019). The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis. Pancreatology, 19(4), 531-534.

Cui, Y., Jiao, Y., Wang, K., He, M., & Yang, Z. (2019). A new prognostic factor of breast cancer: High carboxyl ester lipase expression related to poor survival. Cancer genetics, 239, 54-61.

Johansson, B. B., Fjeld, K., El Jellas, K., Gravdal, A., Dalva, M., Tjora, E., ... & Molven, A. (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Pancreatology, 18(1), 12-19.

El Jellas, K., Johansson, B. B., Fjeld, K., Antonopoulos, A., Immervoll, H., Choi, M. H., ... & Molven, A. (2018). The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. Journal of Biological Chemistry, 293(50), 19476-19491.

Dalva, M., El Jellas, K., Steine, S. J., Johansson, B. B., Ringdal, M., Torsvik, J., ... & Molven, A. (2017). Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. Pancreatology, 17(1), 83-88.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant CEL protein, His Tag (CAT#: V2LY-0526-LY8098)

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Mouse Anti-CEL Recombinant Antibody (C5830) (CAT#: CBMAB-C5830-LY)

Mouse Anti-CEL Recombinant Antibody (AP1448) (CAT#: CBMAB-AP1448LY)

Mouse Anti-CEL Recombinant Antibody (CBWJC-2466) (CAT#: CBMAB-C3534WJ)

Mouse Recombinant CEL protein, His Tag (CAT#: V2LY-0526-LY8098)

Mouse Anti-CEL Recombinant Antibody (CBXC-0361) (CAT#: CBMAB-C4597-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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