Mouse Gpx2 ELISA Kit (V2LY-0626-LY5884)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.052 ng/mL
Detection Range
0.1-40 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
22.0 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
glutathione peroxidase 2
Function
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Biological Process
Response to oxidative stress Source: InterPro
Cellular Location
Cytoplasm. Mainly cytoplasmic.

Xu, H., Hu, C., Wang, Y., Shi, Y., Yuan, L., Xu, J., ... & Cheng, X. (2023). Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism. Oncogene, 1-13.

Cui, Z., Xu, L., Wu, H., Wang, M., Lu, L., & Wu, S. (2023). Glutathione peroxidase 2: A key factor in the development of microsatellite instability in colon cancer. Pathology-Research and Practice, 243, 154372.

Ren, Z., Liang, H., Galbo Jr, P. M., Dharmaratne, M., Kulkarni, A. S., Fard, A. T., ... & Hazan, R. B. (2022). Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer. Proceedings of the National Academy of Sciences, 119(8), e2107266119.

Wang, M., Chen, X., Fu, G., & Ge, M. (2022). Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS‑mutated lung cancer cells. Oncology Reports, 48(6), 1-14.

Ahmed, K. M., Veeramachaneni, R., Deng, D., Putluri, N., Putluri, V., Cardenas, M. F., ... & Frederick, M. J. (2022). Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response. Journal for immunotherapy of cancer, 10(8), e004752.

Canizal-García, M., Olmos-Orizaba, B. E., Moreno-Jiménez, M., Calderón-Cortés, E., Saavedra-Molina, A., & Cortés-Rojo, C. (2021). Glutathione peroxidase 2 (Gpx2) preserves mitochondrial function and decreases ROS levels in chronologically aged yeast. Free Radical Research, 55(2), 165-175.

Guo, B., Liao, W., & Wang, S. (2021). The clinical significance of glutathione peroxidase 2 in glioblastoma multiforme. Translational neuroscience, 12(1), 032-039.

Du, H., Chen, B., Jiao, N. L., Liu, Y. H., Sun, S. Y., & Zhang, Y. W. (2020). Elevated glutathione peroxidase 2 expression promotes cisplatin resistance in lung adenocarcinoma. Oxidative Medicine and Cellular Longevity, 2020.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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