Mouse Recombinant CCL17 protein (V2LY-0526-LY8948)

Name: Mouse Recombinant CCL17 protein
SKU: V2LY-0526-LY8948
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Mouse

Protein Construction

This product is Mouse Recombinant CCL17 protein consist of Amino Acid: 1-93 and predicts a molecular mass of 8.2 kDa.

Molecule Mass

8.2 kDa

Sequence

Amino Acid: 1-93

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>98% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chemokine (C-C motif) ligand 17

Function

Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Multicellular organism development Source: ProtInc
Negative regulation of myoblast differentiation Source: Ensembl
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central

Cellular Location

Secreted

Tang, N., Zhang, Y. Y., Cheng, J. H., Zhao, Z. B., & Fan, Y. (2021). Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology, 39(4), 405-412.

Feng, S., Wang, L., Wang, Y., Wang, Y., Chen, Y., Tian, R., ... & Zhang, S. (2021). Association between serum chemokine CC-motif ligand 17 and prognosis of patients at risk for coronary heart disease.

Dong, Y., Gao, S., Zhang, X., Kou, J., Liu, J., Ye, T., & Shen, H. (2021). CCL17 and CCL22 induce CCR4 receptor expression and promote cytokine-induced killer cells migration. Anti-cancer Drugs.

Chen, Y. T., Hsu, H., Lin, C. C., Pan, S. Y., Liu, S. Y., Wu, C. F., ... & Lin, S. L. (2020). Inflammatory macrophages switch to CCL17‐expressing phenotype and promote peritoneal fibrosis. The Journal of pathology, 250(1), 55-66.

Wilkinson, H. N., Roberts, E. R., Stafford, A. R., Banyard, K. L., Matteucci, P., Mace, K. A., & Hardman, M. J. (2019). Tissue iron promotes wound repair via m2 macrophage polarization and the chemokine (cc motif) ligands 17 and 22. The American journal of pathology, 189(11), 2196-2208.

Li, J., Yang, C., Yang, J., & Zou, L. (2019). Down-regulation of CCL17 in cancer-associated fibroblasts inhibits cell migration and invasion of breast cancer through ERK1/2 pathway. Cancer management and research, 11, 7439.

Lee, M. C., Saleh, R., Achuthan, A., Fleetwood, A. J., Förster, I., Hamilton, J. A., & Cook, A. D. (2018). CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis research & therapy, 20(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CCL17 protein (CAT#: V2LY-0526-LY7058)

Human Recombinant CCL17 protein, His Tag (CAT#: V2LY-0526-LY7059)

Rhesus Recombinant CCL17 protein, His Tag (CAT#: V2LY-0526-LY9793)

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Rhesus Recombinant CCL17 protein, His Tag (CAT#: V2LY-0526-LY9793)

Human Recombinant CCL17 protein (CAT#: V2LY-0526-LY7058)

Mouse Anti-CCL17 Recombinant Antibody (1F11) (CAT#: CBMAB-C4014-LY)

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Rat Anti-CCL17 Recombinant Antibody (9K49) (CAT#: CBMAB-C9804-LY)

Rat Anti-CCL17 Recombinant Antibody (110946) (CAT#: CBMAB-C0198-LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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