Mouse Recombinant CCL7 protein, His Tag (V2LY-0526-LY8649)

Name: Mouse Recombinant CCL7 protein, His Tag
SKU: V2LY-0526-LY8649
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant CCL7 protein, His Tag consist of Amino Acid: 24-97 and predicts a molecular mass of 10.7 kDa.

Molecule Mass

10.7 kDa

Sequence

Amino Acid: 24-97

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Ligand 7

Function

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Biological Process

Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to ethanol Source: Ensembl
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell migration Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of natural killer cell chemotaxis Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to gamma radiation Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

O-glycosylated.

Waśkiel-Burnat, A., Niemczyk, A., Blicharz, L., Chmielińska, P., Zaremba, M., Gąsecka, A., ... & Rudnicka, L. (2021). Chemokine CC Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study. Journal of Clinical Medicine, 10(22), 5418.

Jeong, M., Wang, Y. Y., Choi, J. Y., Lim, M. C., & Choi, J. H. (2021). CC Chemokine Ligand 7 Derived from Cancer-Stimulated Macrophages Promotes Ovarian Cancer Cell Invasion. Cancers, 13(11), 2745.

Niu, M., Luo, Z., Gong, S., Win, S., Kaplowitz, N., Jiang, Y., & Chen, P. (2020). Intestinal epithelial chemokine (CC motif) ligand 7 overexpression enhances acetaminophen-induced hepatotoxicity in mice. The American journal of pathology, 190(1), 57-67.

Chen, J., Dang, Y., Feng, W., Qiao, C., Liu, D., Zhang, T., ... & Xia, L. (2020). SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7. Oncogene, 39(33), 5536-5552.

Kurzejamska, E., Sacharczuk, M., Landázuri, N., Kovtonyuk, O., Lazarczyk, M., Ananthaseshan, S., ... & Religa, P. (2019). Effect of chemokine (CC motif) ligand 7 (CCL7) and its receptor (CCR2) expression on colorectal Cancer behaviors. International journal of molecular sciences, 20(3), 686.

Mariya, S. S., Dewi, F. N., Villiandra, V., Paramastri, Y. A., Iskandriati, D., Saepuloh, U., ... & Sajuthi, D. (2019). Isolation and characterization of CC chemokine ligand 7 (CCL7) in cynomolgus macaques. HAYATI Journal of Biosciences, 26(3), 129-129.

Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H., ... & Yang, X. (2018). The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer. Experimental and therapeutic medicine, 16(4), 3004-3010.

Liu, Y., Cai, Y., Liu, L., Wu, Y., & Xiong, X. (2018). Crucial biological functions of CCL7 in cancer. PeerJ, 6, e4928.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CCL7 protein, His Tag (CAT#: V2LY-0526-LY5481)

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Human Recombinant CCL7 protein, His Tag (CAT#: V2LY-0526-LY5481)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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