Mouse Recombinant MSR1 protein, His Tag (V2LY-0526-LY7975)

Name: Mouse Recombinant MSR1 protein, His Tag
SKU: V2LY-0526-LY7975
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant MSR1 protein, His Tag consist of Amino Acid: 83-354 and predicts a molecular mass of 32 kDa.

Molecule Mass

32 kDa

Sequence

Amino Acid: 83-354

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Macrophage Scavenger Receptor 1

Function

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254).

Isoform III does not internalize acetylated LDL (PubMed:9548586).

Biological Process

Amyloid-beta clearance Source: ARUK-UCL
Cellular response to organic cyclic compound Source: Ensembl
Cholesterol transport Source: BHF-UCL
Lipoprotein transport Source: Ensembl
Negative regulation of gene expression Source: ARUK-UCL
Phagocytosis, engulfment Source: ARUK-UCL
Plasma lipoprotein particle clearance Source: BHF-UCL
Positive regulation of cholesterol storage Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Receptor-mediated endocytosis Source: ARUK-UCL

Cellular Location

Membrane

Involvement in disease

Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

Topology

Cytoplasmic: 1-50
Helical: 51-76
Extracellular: 77-451

Onyishi, C. U., Desanti, G. E., Wilkinson, A. L., Lara-Reyna, S., Frickel, E. M., Fejer, G., ... & May, R. C. (2023). Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen. Nature Communications, 14(1), 4895.

Baos, S., Cremades-Jimeno, L., López-Ramos, M., de Pedro, M. Á., Uriarte, S. A., Sastre, J., ... & Cárdaba, B. (2022). Expression of macrophage scavenger receptor (MSR1) in peripheral blood cells from patients with different respiratory diseases: Beyond monocytes. Journal of Clinical Medicine, 11(5), 1439.

Gudgeon, J., Marín-Rubio, J. L., & Trost, M. (2022). The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. Frontiers in Immunology, 13, 1012002.

Govaere, O., Petersen, S. K., Martinez-Lopez, N., Wouters, J., Van Haele, M., Mancina, R. M., ... & Härtlova, A. (2022). Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease. Journal of hepatology, 76(5), 1001-1012.

Sheng, W., Ji, G., & Zhang, L. (2022). Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. Frontiers in Immunology, 13, 1050984.

Li, B., Chen, M., Aguzzi, A., & Zhu, C. (2021). The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine, 99, 877-887.

Zheng, M., Tian, T., Liang, J., Ye, S., Chen, J., & Ji, Y. (2021). High-expressed macrophage scavenger receptor 1 predicts severity clinical outcome in transplant patient in idiopathic pulmonary fibrosis disease. Journal of Immunology Research, 2021.

Yang, L., Geng, T., Yang, G., Ma, J., Wang, L., Ketkar, H., ... & Wang, P. (2020). Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology, 3(1), 556.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant MSR1 protein, His Tag (CAT#: V2LY-0526-LY2738)

Rat Recombinant MSR1 protein, hFc Tag (CAT#: V2LY-0526-LY9217)

Rat Recombinant MSR1 protein, His Tag (CAT#: V2LY-0526-LY9218)

Mouse Msr1 ELISA Kit (CAT#: V2LY-0626-LY2590)

Human MSR1 ELISA Kit (CAT#: V2LY-0626-LY4850)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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