Mouse Recombinant OSM protein (V2LY-0526-LY8722)

Name: Mouse Recombinant OSM protein
SKU: V2LY-0526-LY8722
Rating: 5 (1 reviews)

See all OSM antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Protein Construction

This product is Mouse Recombinant OSM protein consist of Amino Acid: 24-206 and predicts a molecular mass of 20.7 kDa.

Molecule Mass

20.7 kDa

Sequence

Amino Acid: 24-206

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Oncostatin M

Function

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Biological Process

Immune responseIEA:InterPro
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:CACAO
Regulation of growthIEA:UniProtKB-KW
Regulation of hematopoietic stem cell differentiationManual Assertion Based On ExperimentTAS:GO_Central

Cellular Location

Secreted

PTM

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.

Hioki, T., Tachi, J., Ueda, K., Matsushima‑Nishiwaki, R., Iida, H., Kozawa, O., & Tokuda, H. (2024). Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony‑stimulating factor synthesis in bFGF‑stimulated osteoblast‑like cells. Experimental and Therapeutic Medicine, 27(1), 1-9.

Polak, K. L., Tamagno, I., Parameswaran, N., Smigiel, J., Chan, E. R., Yuan, X., ... & Jackson, M. W. (2023). Oncostatin-M and OSM-Receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs. Molecular Cancer Research, 21(9), 975-990.

Yang, X., Shao, C., Duan, L., Hou, X., Huang, Y., Gao, L., ... & Wei, L. (2021). Oncostatin M promotes hepatic progenitor cell activation and hepatocarcinogenesis via macrophage-derived tumor necrosis factor-α. Cancer Letters, 517, 46-54.

Verstockt, S., Verstockt, B., Machiels, K., Vancamelbeke, M., Ferrante, M., Cleynen, I., ... & Vermeire, S. (2021). Oncostatin M is a biomarker of diagnosis, worse disease prognosis, and therapeutic nonresponse in inflammatory bowel disease. Inflammatory bowel diseases, 27(10), 1564-1575.

Tseng, P. Y., & Hoon, M. A. (2021). Oncostatin M can sensitize sensory neurons in inflammatory pruritus. Science translational medicine, 13(619), eabe3037.

Masjedi, A., Hajizadeh, F., Dargani, F. B., Beyzai, B., Aksoun, M., Hojjat-Farsangi, M., ... & Jadidi-Niaragh, F. (2021). Oncostatin M: A mysterious cytokine in cancers. International Immunopharmacology, 90, 107158.

Chen, M., Ren, R., Lin, W., Xiang, L., Zhao, Z., & Shao, B. (2021). Exploring the oncostatin M (OSM) feed-forward signaling of glioblastoma via STAT3 in pan-cancer analysis. Cancer cell international, 21, 1-19.

Piquer-Garcia, I., Campderros, L., Taxerås, S. D., Gavaldà-Navarro, A., Pardo, R., Vila, M., ... & Sánchez-Infantes, D. (2020). A role for oncostatin M in the impairment of glucose homeostasis in obesity. The Journal of Clinical Endocrinology & Metabolism, 105(3), e337-e348.

Houben, E., Hellings, N., & Broux, B. (2019). Oncostatin M, an underestimated player in the central nervous system. Frontiers in immunology, 10, 455653.

Stawski, L., & Trojanowska, M. (2019). Oncostatin M and its role in fibrosis. Connective tissue research, 60(1), 40-49.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Recombinant OSM protein?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant OSM protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5873)

Human Recombinant OSM protein, His Tag (CAT#: V2LY-0526-LY5874)

Human Recombinant OSM protein (CAT#: V2LY-0526-LY5876)

Human Recombinant OSMR protein, His Tag (CAT#: V2LY-0526-LY5881)

Human Recombinant OSMR protein, His Tag-1 (CAT#: V2LY-0526-LY5882)

Mouse Recombinant OSM protein, His Tag (CAT#: V2LY-0526-LY8723)

Mouse Recombinant OSM protein, Biotin Conjugated, (CAT#: V2LY-0526-LY8724)

Mouse Recombinant OSMR protein, His Tag (CAT#: V2LY-0526-LY8726)

Human Recombinant OSM, GMP grade protein (CAT#: V2LY-0526-LY5875)

Related Products

Rabbit Anti-OSM Recombinant Antibody (CBXO-0172) (CAT#: CBMAB-O0448-CQ)

Human Anti-OSM Recombinant Antibody (
31E7) (CAT#: V2LY-0725-LY838)

Mouse Recombinant OSM protein, His Tag (CAT#: V2LY-0526-LY8723)

Human Recombinant OSM protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY5873)

Mouse Anti-OSM Recombinant Antibody (CBXO-0082) (CAT#: CBMAB-O0619-CQ)

Rat Anti-OSM (AA 24-206) Recombinant Antibody (CBXO-0398) (CAT#: CBMAB-O0018-CQ)

Mouse Anti-OSM (AA 26-221) Recombinant Antibody (CBXO-0363) (CAT#: CBMAB-O0009-CQ)

Mouse Anti-OSM Recombinant Antibody (17001.31) (CAT#: CBMAB-O0008-CQ)

Rat Anti-OSM Recombinant Antibody (CBXO-0240) (CAT#: CBMAB-O0450-CQ)

Human Recombinant OSM protein (CAT#: V2LY-0526-LY5876)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry