Mouse Recombinant PROC protein, His Tag (V2LY-0526-LY8805)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of blood coagulationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of coagulationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Proteolysis1 PublicationIDA:ComplexPortal
Golgi apparatus
Endoplasmic reticulum
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency.
Thrombophilia due to protein C deficiency, autosomal recessive (THPH4):
A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant Protein C protein, His Tag (CAT#: V2LY-0526-LY6345)
Antibody Pairs
PROC Matched Antibody Pair (933) (CAT#: APMAB-933LY)
Related Products
Mouse Anti-PROC Recombinant Antibody (10g216) (CAT#: CBMAB-P2955-YC)
PROC Matched Antibody Pair (933) (CAT#: APMAB-933LY)
Mouse Anti-PROC Recombinant Antibody (CBYC-P646) (CAT#: CBMAB-P2964-YC)
Mouse Anti-PROC Recombinant Antibody (CBFYC-0198) (CAT#: CBMAB-C0223-FY)
Rat Anti-PROC Recombinant Antibody (CBYC-P643) (CAT#: CBMAB-P2960-YC)
Mouse Anti-PROC Recombinant Antibody (CBYC-A1028) (CAT#: CBMAB-A4683-YC)
Mouse Anti-PROC Recombinant Antibody (1E6) (CAT#: CBMAB-P2956-YC)
Rat Anti-PROC Recombinant Antibody (CBYC-P645) (CAT#: CBMAB-P2963-YC)
Mouse Anti-PROC Recombinant Antibody (CBYC-A1026) (CAT#: CBMAB-A4681-YC)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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