Mouse Recombinant SLAMF7 protein, His Tag (V2LY-0526-LY8916)

Name: Mouse Recombinant SLAMF7 protein, His Tag
SKU: V2LY-0526-LY8916
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant SLAMF7 protein, His Tag consist of Amino Acid: 1-224 and predicts a molecular mass of 23.7 kDa.

Molecule Mass

23.7 kDa

Verified

HPLC

Sequence

Amino Acid: 1-224

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

SLAM Family Member 7

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418).
Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536).
In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity).
May play a role in lymphocyte adhesion (PubMed:11802771).
In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process natural killer cell activation1 PublicationNAS:UniProtKB
Biological Process natural killer cell mediated cytotoxicity1 PublicationNAS:UniProtKB
Biological Process T cell activationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 23-226
Helical: 227-247
Cytoplasmic: 248-335

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SLAMF7 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY6848)

Human Recombinant SLAMF7 protein, ECD, His Tag (CAT#: V2LY-0526-LY6849)

Human Recombinant SLAMF7 protein, Biotin Conjugated, hFc Tag (CAT#: V2LY-0526-LY6850)

Human Recombinant SLAMF7 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY6851)

Human Recombinant SLAMF7 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY6852)

Human Recombinant SLAMF7 protein, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY6853)

Human Recombinant SLAMF7 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY6854)

Human Recombinant SLAMF7 protein, PE Conjugated, His Tag (CAT#: V2LY-0526-LY6855)

Related Products

Human Recombinant SLAMF7 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY6848)

Rabbit Anti-SLAMF7 Recombinant Antibody (002) (CAT#: CBMAB-C1486-LY)

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-0321) (CAT#: CBMAB-C0357-FY)

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-3120) (CAT#: CBMAB-C3197-FY)

Human Recombinant SLAMF7 protein, AF488 Conjugated, His Tag (CAT#: V2LY-0526-LY6852)

Mouse Anti-SLAMF7 Recombinant Antibody (CBFYC-0459) (CAT#: CBMAB-C0505-FY)

Mouse Anti-SLAMF7 Recombinant Antibody (162) (CAT#: CBMAB-C0395-LY)

Rabbit Anti-SLAMF7 Recombinant Antibody (E5C4M) (CAT#: CBMAB-CP2460-LY)

Human Recombinant SLAMF7 protein, Biotin Conjugated, hFc Tag (CAT#: V2LY-0526-LY6850)

Mouse Anti-SLAMF7 Recombinant Antibody (162.1) (CAT#: CBMAB-C0396-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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