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NEIL1 Matched Antibody Pair (786) (APMAB-786LY)

This antibody pair set can be used for detecting and quantifying protein level of human NEIL1.
See all NEIL1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NEIL1 polyclonal antibody, 100 ug
Detection Antibody
Anti-NEIL1 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Alternative Names
Nei Like DNA Glycosylase 1; DNA-(Apurinic Or Apyrimidinic Site) Lyase Neil1; DNA Endonuclease Eight-Like Glycosylase 1; DNA Glycosylase/AP Lyase Neil1; Endonuclease VIII-Like 1; Nei-Like Protein 1; Nei Homolog 1; FPG1; NEH1;
Entrez Gene ID
79661
UniProt ID
Q96FI4

Cao, J. H., Cao, C. H., Lin, J. L., Li, S. Y., He, L. J., Han, K., ... & Wang, F. W. (2024). NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1. Cell Reports, 43(1), 113654-113654.

Lloyd, R. S. (2022). Complex roles of NEIL1 and OGG1: insights gained from murine knockouts and human polymorphic variants. DNA, 2(4), 279-301.

Lotsof, E. R., Krajewski, A. E., Anderson-Steele, B., Rogers, J., Zhang, L., Yeo, J., ... & David, S. S. (2022). NEIL1 recoding due to RNA editing impacts lesion-specific recognition and excision. Journal of the American Chemical Society, 144(32), 14578-14589.

Hanna, B. M., Michel, M., Helleday, T., & Mortusewicz, O. (2021). NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487. International Journal of Molecular Sciences, 22(9), 4542.

Yeo, J., Lotsof, E. R., Anderson-Steele, B. M., & David, S. S. (2021). RNA editing of the human DNA glycosylase NEIL1 alters its removal of 5-hydroxyuracil lesions in DNA. Biochemistry, 60(19), 1485-1497.

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Coskun, E., Coskun, S. H., Jaruga, P., ... & Lloyd, R. S. (2020). Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1. DNA repair, 85, 102741.

Albelazi, M. S., Martin, P. R., Mohammed, S., Mutti, L., Parsons, J. L., & Elder, R. H. (2019). The biochemical role of the human NEIL1 and NEIL3 DNA glycosylases on model DNA replication forks. Genes, 10(4), 315.

Kladova, O. A., Grin, I. R., Fedorova, O. S., Kuznetsov, N. A., & Zharkov, D. O. (2019). Conformational dynamics of damage processing by human DNA glycosylase NEIL1. Journal of molecular biology, 431(6), 1098-1112.

Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L., & Bohr, V. A. (2019). NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress. Free Radical Biology and Medicine, 141, 47-58.

Han, D., Schomacher, L., Schüle, K. M., Mallick, M., Musheev, M. U., Karaulanov, E., ... & Niehrs, C. (2019). NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. elife, 8, e49044.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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