Rabbit Anti-GOT1 Recombinant Antibody (CP0859) (V2LY-0226-LY445)

Name: Rabbit Anti-GOT1 Recombinant Antibody (CP0859)
SKU: V2LY-0226-LY445
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CP0859

Application

WB, IHC, IF, FC

Immunogen

Human GOT1.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, BSA, glycerol

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Glutamic-Oxaloacetic Transaminase 1

Entrez Gene ID

2805

UniProt ID

P17174

Function

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Biological Process

2-oxoglutarate metabolic process Source: UniProtKB
Aspartate biosynthetic process Source: GO_Central
Aspartate catabolic process Source: UniProtKB
Aspartate metabolic process Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Cellular response to mechanical stimulus Source: Ensembl
Fatty acid homeostasis Source: Ensembl
Glutamate catabolic process to 2-oxoglutarate Source: Ensembl
Glutamate catabolic process to aspartate Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glycerol biosynthetic process Source: UniProtKB
Negative regulation of collagen biosynthetic process Source: Ensembl
Negative regulation of cytosolic calcium ion concentration Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Notch signaling pathway Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to carbohydrate Source: Ensembl
Response to glucocorticoid Source: UniProtKB
Response to immobilization stress Source: Ensembl
Response to transition metal nanoparticle Source: Ensembl
Transdifferentiation Source: Ensembl

Cellular Location

Cytoplasm

Song, Z., Yang, Y., Wu, Y., Zheng, M., Sun, D., Li, H., & Chen, L. (2022). Glutamic oxaloacetic transaminase 1 as a potential target in human cancer. European Journal of Pharmacology, 174754.

Yang, Y., Cheng, Z., Zhang, W., Hei, W., Lu, C., Cai, C., ... & Li, B. (2022). Glutamic-oxaloacetic transaminase 1 regulates adipocyte differentiation by altering nicotinamide adenine dinucleotide phosphate content. Animal Bioscience, 35(2), 155.

Deng, Y., Lai, W., Yu, L., Zhang, W., & Ding, Y. (2022). miR-2115-3p inhibits ferroptosis by downregulating the expression of glutamic-oxaloacetic transaminase in preeclampsia. Placenta, 129, 94-103.

Cheng, Z., Dai, Y., Zeng, T., Liu, Y., Cui, L., Qian, T., ... & Fu, L. (2020). Upregulation of glutamic-oxaloacetic transaminase 1 predicts poor prognosis in acute myeloid leukemia. Frontiers in oncology, 10, 379.

Weißhaar, N. K. (2020). The malate aspartate shuttle in T cell metabolic fitness: Glutamic oxaloacetic transaminase 1 antagonizes T cell exhaustion (Doctoral dissertation).

Wang, Q., Zhang, Q., Luan, S., Yang, K., Zheng, M., Li, K., ... & Li, H. (2019). Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorganic Chemistry, 93, 103315.

Zhang, K., Wu, L., Zhang, P., Luo, M., Du, J., Gao, T., ... & Yang, Y. (2018). miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma. Molecular carcinogenesis, 57(11), 1566-1576.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GOT1 Matched Antibody Pair (493) (CAT#: APMAB-493LY)

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Rat Got1 ELISA Kit (CAT#: V2LY-0626-LY1423)

GOT1 Matched Antibody Pair (493) (CAT#: APMAB-493LY)

Pig GOT1 ELISA Kit (CAT#: V2LY-0626-LY929)

Mouse Anti-GOT1 Recombinant Antibody (4G4) (CAT#: V2LY-0226-LY437)

Mouse Anti-GOT1 Recombinant Antibody (CBLG1-1541) (CAT#: V2LY-0226-LY438)

Human Recombinant Aspartate Aminotransferase protein, His Tag (CAT#: V2LY-0526-LY2187)

Mouse Anti-GOT1 Recombinant Antibody (CBYC-A964) (CAT#: V2LY-0226-LY443)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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