Rat Maob ELISA Kit (V2LY-0626-LY2046)

Name: Rat Maob ELISA Kit
SKU: V2LY-0626-LY2046
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

1.12 U/mL

Detection Range

2-700 U/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Molecule Mass

58.5 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Monoamine Oxidase B

Function

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).
Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).

Biological Process

Dopamine catabolic processManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Hydrogen peroxide biosynthetic process1 PublicationNAS:ParkinsonsUK-UCL
Negative regulation of serotonin secretionIEA:Ensembl
Neurotransmitter catabolic processIEA:Ensembl
Positive regulation of dopamine metabolic processIEA:Ensembl
Response to aluminum ionIEA:Ensembl
Response to corticosteroneIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to selenium ionIEA:Ensembl
Response to toxic substanceIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Mitochondrion outer membrane

Topology

Cytoplasmic: 2-489
Helical: 490-516
Mitochondrial intermembrane: 517-520

Meyer, J. H., & Braga, J. (2022). Development and clinical application of positron emission tomography imaging agents for monoamine oxidase B. Frontiers in Neuroscience, 15, 773404.

Tan, Y. Y., Jenner, P., & Chen, S. D. (2022). Monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease: past, present, and future. Journal of Parkinson's Disease, 12(2), 477-493.

Huang, Y. H., Chen, J. H., Loh, E. W., Chan, L., & Hong, C. T. (2021). The effect of monoamine oxidase-B inhibitors on the alleviation of depressive symptoms in Parkinson’s disease: meta-analysis of randomized controlled trials. Therapeutic advances in psychopharmacology, 11, 2045125320985993.

Özdemir, Z., Alagöz, M. A., Bahçecioğlu, Ö. F., & Gök, S. (2021). Monoamine oxidase-B (MAO-B) inhibitors in the treatment of Alzheimer’s and Parkinson’s disease. Current medicinal chemistry, 28(29), 6045-6065.

Höfs, S., Greiner, T., Göbel, G., Talke, A., & Lisdat, F. (2021). Activity determination of human monoamine oxidase B (Mao B) by selective capturing and amperometric hydrogen peroxide detection. Sensors and Actuators B: Chemical, 328, 129020.

Jin, C. F., Wang, Z. Z., Chen, K. Z., Xu, T. F., & Hao, G. F. (2020). Computational fragment-based design facilitates discovery of potent and selective monoamine oxidase-B (MAO-B) inhibitor. Journal of Medicinal Chemistry, 63(23), 15021-15036.

Kavully, F. S., Oh, J. M., Dev, S., Kaipakasseri, S., Palakkathondi, A., Vengamthodi, A., ... & Mathew, B. (2020). Design of enamides as new selective monoamine oxidase-B inhibitors. Journal of Pharmacy and Pharmacology, 72(7), 916-926.

Tabata, Y., & Shidoji, Y. (2020). Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells [S]. Journal of Lipid Research, 61(5), 778-789.

Tripathi, R. K. P., & Ayyannan, S. R. (2019). Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update. Medicinal research reviews, 39(5), 1603-1706.

Müller, T., & Möhr, J. D. (2019). Pharmacokinetics of monoamine oxidase B inhibitors in Parkinson’s disease: current status. Expert Opinion on Drug Metabolism & Toxicology, 15(5), 429-435.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Maob ELISA Kit (CAT#: V2LY-0626-LY2016)

Human MAOB ELISA Kit (CAT#: V2LY-0626-LY3806)

Pig MAOB ELISA Kit (CAT#: V2LY-0626-LY928)

Related Products

Mouse Anti-MAOB Recombinant Antibody (A981) (CAT#: CBMAB-AP11666LY)

Mouse Maob ELISA Kit (CAT#: V2LY-0626-LY2016)

Human MAOB ELISA Kit (CAT#: V2LY-0626-LY3806)

Mouse Anti-MAOB Recombinant Antibody (CBFYM-1373) (CAT#: CBMAB-M1532-FY)

Pig MAOB ELISA Kit (CAT#: V2LY-0626-LY928)

Rabbit Anti-MAOB Recombinant Antibody (
9B6) (CAT#: V2LY-0725-LY1596)

Mouse Anti-MAOB Recombinant Antibody (CF277) (CAT#: CBMAB-FT218LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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