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Mouse Anti-MAOB Recombinant Antibody (CBFYM-1373) (CBMAB-M1532-FY)

This product is mouse antibody that recognizes MAOB. The antibody CBFYM-1373 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MAOB antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-1373
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Monoamine Oxidase B
Introduction
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.
Entrez Gene ID
Human4129
Mouse109731
Rat25750
UniProt ID
HumanP27338
MouseQ8BW75
RatP19643
Alternative Names
Monoamine Oxidase B; Monoamine Oxidase Type B; EC 1.4.3.4; MAO-B; Amine Oxidase [Flavin-Containing] B; Adrenalin Oxidase
Function
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).
Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).
Biological Process
Dopamine catabolic processManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Hydrogen peroxide biosynthetic process1 PublicationNAS:ParkinsonsUK-UCL
Negative regulation of serotonin secretionIEA:Ensembl
Neurotransmitter catabolic processIEA:Ensembl
Positive regulation of dopamine metabolic processIEA:Ensembl
Response to aluminum ionIEA:Ensembl
Response to corticosteroneIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to selenium ionIEA:Ensembl
Response to toxic substanceIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Mitochondrion outer membrane
Topology
Cytoplasmic: 2-489
Helical: 490-516
Mitochondrial intermembrane: 517-520

Meyer, J. H., & Braga, J. (2022). Development and clinical application of positron emission tomography imaging agents for monoamine oxidase B. Frontiers in Neuroscience, 15, 773404.

Tan, Y. Y., Jenner, P., & Chen, S. D. (2022). Monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease: past, present, and future. Journal of Parkinson's Disease, 12(2), 477-493.

Huang, Y. H., Chen, J. H., Loh, E. W., Chan, L., & Hong, C. T. (2021). The effect of monoamine oxidase-B inhibitors on the alleviation of depressive symptoms in Parkinson’s disease: meta-analysis of randomized controlled trials. Therapeutic advances in psychopharmacology, 11, 2045125320985993.

Özdemir, Z., Alagöz, M. A., Bahçecioğlu, Ö. F., & Gök, S. (2021). Monoamine oxidase-B (MAO-B) inhibitors in the treatment of Alzheimer’s and Parkinson’s disease. Current medicinal chemistry, 28(29), 6045-6065.

Höfs, S., Greiner, T., Göbel, G., Talke, A., & Lisdat, F. (2021). Activity determination of human monoamine oxidase B (Mao B) by selective capturing and amperometric hydrogen peroxide detection. Sensors and Actuators B: Chemical, 328, 129020.

Jin, C. F., Wang, Z. Z., Chen, K. Z., Xu, T. F., & Hao, G. F. (2020). Computational fragment-based design facilitates discovery of potent and selective monoamine oxidase-B (MAO-B) inhibitor. Journal of Medicinal Chemistry, 63(23), 15021-15036.

Kavully, F. S., Oh, J. M., Dev, S., Kaipakasseri, S., Palakkathondi, A., Vengamthodi, A., ... & Mathew, B. (2020). Design of enamides as new selective monoamine oxidase-B inhibitors. Journal of Pharmacy and Pharmacology, 72(7), 916-926.

Tabata, Y., & Shidoji, Y. (2020). Hepatic monoamine oxidase B is involved in endogenous geranylgeranoic acid synthesis in mammalian liver cells [S]. Journal of Lipid Research, 61(5), 778-789.

Tripathi, R. K. P., & Ayyannan, S. R. (2019). Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update. Medicinal research reviews, 39(5), 1603-1706.

Müller, T., & Möhr, J. D. (2019). Pharmacokinetics of monoamine oxidase B inhibitors in Parkinson’s disease: current status. Expert Opinion on Drug Metabolism & Toxicology, 15(5), 429-435.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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