MAOB

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

Full Name

Monoamine Oxidase B

Function

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).
Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079).

Biological Process

Dopamine catabolic processManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Hydrogen peroxide biosynthetic process1 PublicationNAS:ParkinsonsUK-UCL
Negative regulation of serotonin secretionIEA:Ensembl
Neurotransmitter catabolic processIEA:Ensembl
Positive regulation of dopamine metabolic processIEA:Ensembl
Response to aluminum ionIEA:Ensembl
Response to corticosteroneIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to selenium ionIEA:Ensembl
Response to toxic substanceIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Mitochondrion outer membrane

Topology

Cytoplasmic: 2-489
Helical: 490-516
Mitochondrial intermembrane: 517-520