Rat Slc2a4 ELISA Kit (V2LY-0626-LY915)

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Tested Data
Request for COA
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Basic Information

Sensitivity
0.11 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
54.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Solute Carrier Family 2 Member 4
Function
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Biological Process
Biological Process amylopectin biosynthetic processIEA:Ensembl
Biological Process brown fat cell differentiationIEA:Ensembl
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to osmotic stressIEA:Ensembl
Biological Process cellular response to tumor necrosis factorIEA:Ensembl
Biological Process glucose homeostasisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glucose import1 PublicationNAS:BHF-UCL
Biological Process glucose import in response to insulin stimulusISS:UniProtKB
Biological Process glucose transmembrane transportISS:UniProtKB
Biological Process learning or memoryISS:ARUK-UCL
Biological Process long-term memoryISS:ARUK-UCL
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of brain-derived neurotrophic factor receptor signaling pathwayISS:ARUK-UCL
Biological Process regulation of synaptic vesicle budding from presynaptic endocytic zone membraneIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process short-term memoryISS:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Endomembrane system
Cytoplasm, perinuclear region
Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557).
The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557).
Insulin stimulation induces translocation to the cell membrane (By similarity)
Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
PTM
Sumoylated.
Palmitoylated (PubMed:28057756).
Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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