ADRA2C

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Full Name

Adrenoceptor Alpha 2C

Function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Biological Process

Activation of protein kinase B activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adrenergic receptor signaling pathway
Cell-cell signaling
Female pregnancy
G protein-coupled receptor signaling pathway
Negative regulation of epinephrine secretion
Negative regulation of norepinephrine secretion
Negative regulation of uterine smooth muscle contraction
Platelet activation
Positive regulation of MAPK cascade
Positive regulation of neuron differentiation
Positive regulation of vasoconstriction
Receptor transactivation
Regulation of insulin secretion
Regulation of sensory perception of pain

Cellular Location

Cell membrane

Topology

Extracellular: 1-51 aa
Helical: 52-76 aa
Cytoplasmic: 77-88 aa
Helical: 89-114 aa
Extracellular: 115-124 aa
Helical: 125-147 aa
Cytoplasmic: 148-168 aa
Helical: 169-191 aa
Extracellular: 192-207 aa
Helical: 208-231 aa
Cytoplasmic: 232-379 aa
Helical: 380-407 aa
Extracellular: 408-420 aa
Helical: 421-441 aa
Cytoplasmic: 442-462 aa