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Mouse Anti-ADRA2C Recombinant Antibody (V2-180024) (CBMAB-A1417-YC)

Provided herein is a Mouse monoclonal antibody against Human Adrenoceptor Alpha 2C. The antibody can be used for immunoassay techniques, such as ICC, WB.
See all ADRA2C antibodies
Published Data
Fig. 1 Flow cytometry
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180024
Antibody Isotype
IgG
Application
ICC, WB, IP, IHC

Basic Information

Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:5,000
IF(ICC)1:50-1:200
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.09% sodium azide, 50% glycerol
Buffer
PBS pH7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 442-462

Target

Full Name
Adrenoceptor Alpha 2C
Introduction
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic
Entrez Gene ID
152
UniProt ID
P18825
Alternative Names
Adrenoceptor Alpha 2C; Alpha-2 Adrenergic Receptor Subtype C4; Adrenergic, Alpha-2C-, Receptor; Alpha-2C Adrenoreceptor; Alpha-2C Adrenoceptor; Alpha-2CAR; ADRA2RL2;
Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Biological Process
Activation of protein kinase B activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adrenergic receptor signaling pathway
Cell-cell signaling
Female pregnancy
G protein-coupled receptor signaling pathway
Negative regulation of epinephrine secretion
Negative regulation of norepinephrine secretion
Negative regulation of uterine smooth muscle contraction
Platelet activation
Positive regulation of MAPK cascade
Positive regulation of neuron differentiation
Positive regulation of vasoconstriction
Receptor transactivation
Regulation of insulin secretion
Regulation of sensory perception of pain
Cellular Location
Cell membrane
Topology
Extracellular: 1-51 aa
Helical: 52-76 aa
Cytoplasmic: 77-88 aa
Helical: 89-114 aa
Extracellular: 115-124 aa
Helical: 125-147 aa
Cytoplasmic: 148-168 aa
Helical: 169-191 aa
Extracellular: 192-207 aa
Helical: 208-231 aa
Cytoplasmic: 232-379 aa
Helical: 380-407 aa
Extracellular: 408-420 aa
Helical: 421-441 aa
Cytoplasmic: 442-462 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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