Mouse Anti-ADRA2C Recombinant Antibody (V2-12534) (CBMAB-1024-CN)

Name: Mouse Anti-ADRA2C Recombinant Antibody (V2-12534)
SKU: CBMAB-1024-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-12534

Application

WB, IF

Immunogen

Synthetic peptide aa. 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS pH 7.4, 50% glycerol

Preservative

0.09% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adrenoceptor Alpha 2C

Introduction

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Entrez Gene ID

152

UniProt ID

P18825

Alternative Names

ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR

Function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Biological Process

Activation of protein kinase B activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adrenergic receptor signaling pathway
Cell-cell signaling
Female pregnancy
G protein-coupled receptor signaling pathway
Negative regulation of epinephrine secretion
Negative regulation of norepinephrine secretion
Negative regulation of uterine smooth muscle contraction
Platelet activation
Positive regulation of MAPK cascade
Positive regulation of neuron differentiation
Positive regulation of vasoconstriction
Receptor transactivation
Regulation of insulin secretion
Regulation of sensory perception of pain

Cellular Location

Cell membrane

Topology

Extracellular: 1-51 aa
Helical: 52-76 aa
Cytoplasmic: 77-88 aa
Helical: 89-114 aa
Extracellular: 115-124 aa
Helical: 125-147 aa
Cytoplasmic: 148-168 aa
Helical: 169-191 aa
Extracellular: 192-207 aa
Helical: 208-231 aa
Cytoplasmic: 232-379 aa
Helical: 380-407 aa
Extracellular: 408-420 aa
Helical: 421-441 aa
Cytoplasmic: 442-462 aa

Aharon, D., Friedman, E. G., Overbey, J. R., McLaughlin, M. A., Langaee, T., & Thurston, R. C. (2019). The association of an alpha2C adrenoreceptor gene polymorphism with vasomotor symptoms in African American women. Menopause (New York, NY), 26(3), 300.

Schmutz, I., Jagannathan, V., Dìez Bernal, S., Lanz, S., Kalbfleisch, T., Leeb, T., & Spadavecchia, C. (2018). Exclusion of adrenoceptor alpha 2 variants in a horse insensitive to medetomidine. Animal genetics, 49(2), 141.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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