AHCY

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Full Name
Adenosylhomocysteinase
Function
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Biological Process
Chronic inflammatory response to antigenic stimulus
Circadian sleep/wake cycle
Methylation
One-carbon metabolic process
Response to hypoxia
Response to nutrient
S-adenosylhomocysteine catabolic process
S-adenosylmethionine cycle
Sulfur amino acid metabolic process
Cellular Location
Cytoplasm; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Involvement in disease
Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD): A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.
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Anti-AHCY antibodies

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Mouse Anti-AHCY Recombinant Antibody (V2-180267) (CBMAB-A1700-YC)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: V2-180267
Application*: WB
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-634177) (CBMAB-AP217LY)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-634177
Application*: ELISA, IF, IP, WB
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-364473) (CBMAB-S1397-CQ)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-364473
Application*: E, WB, IP, IF
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-180268) (CBMAB-A1701-YC)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-180268
Application*: E, IH, IF, WB
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-180266) (CBMAB-A1699-YC)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180266
Application*: E, WB
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-180265) (CBMAB-A1698-YC)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: V2-180265
Application*: E, WB
Datasheet SDS

Rabbit Anti-AHCY Recombinant Antibody (
13H8) (V2LY-0725-LY1000)

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Target: AHCY
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 13H8
Application*: E, WB
Datasheet SDS

AHCY Matched Antibody Pair (033) (APMAB-033LY)

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Target: AHCY
Specificity: Human
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-633552) (CBMAB-FT459LY)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-633552
Application*: ELISA, IHC, IF, WB
Datasheet SDS

Mouse Anti-AHCY Recombinant Antibody (V2-3427) (CBMAB-0144-CN)

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Target: AHCY
Host: Mouse
Antibody Isotype: IgG1
Specificity: Frog
Clone: V2-3427
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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