Mouse Anti-AHCY Recombinant Antibody (V2-180266) (CBMAB-A1699-YC)

Name: Mouse Anti-AHCY Recombinant Antibody (V2-180266)
SKU: CBMAB-A1699-YC
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-AHCY Recombinant Antibody (M2) (CBMAB-A1699-YC) in WB

Western blot analysis was performed for six pairs of CRC tissue and matched normal tissue samples. -Tubulin was used as control. ...View More

Kim, H. J., Kang, H. J., Lee, H., Lee, S. T., Yu, M. H., Kim, H., & Lee, C. (2009). Identification of S100A8 and S100A9 as serological markers for colorectal cancer. Journal of proteome research, 8(3), 1368-1379.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180266

Application

ELISA, WB

Immunogen

AHCY (AAH11606, 1-432 aa) full-length recombinant protein with GST tag. Immunogen sequence: MSDKLPYKVA DIGLAAWGRK ALDIAENEMP GLMRMRERYS ASKPLKGARI AGCLHMTVET AVLIETLVTL GAEVQWSSCN IFSTQDHAAA AIAKAGIPVY AWKGETDEEY LWCIEQTLYF KDGPLNMILD DGGDLTNLIH TKHPQLLPGI RGISEETTTG VHNLYKMMAN GILKVPAINV NDSVTKSKFD NLYGCRESLI DGIKRATDVM IAGKVAVVAG YGDVGKGCAQ ALRGFGARVI ITEIDPINAL QAAMEGYEVT TMDEACQEGN IFVTTTGCID IILGRHFEQM KDDAIVCNIG HFDVEIDVKW LNENAVEKVN IKPQVDRYRL KNGRRIILLA EGRLVNLGCA MGHPSFVMSN SFTNQVMAQI ELWTHPDKYP VGVHFLPKKL DEAVAEAHLG KLNVKLTKLT EKQAQYLGMS CDGPFKPDHY RY

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adenosylhomocysteinase

Introduction

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocystei

Entrez Gene ID

191

UniProt ID

P23526

Alternative Names

Adenosylhomocysteinase; S-Adenosyl-L-Homocysteine Hydrolase; S-Adenosylhomocysteine Hydrolase; EC 3.3.1.1; AdoHcyase; SAHH;

Function

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

Biological Process

Chronic inflammatory response to antigenic stimulus
Circadian sleep/wake cycle
Methylation
One-carbon metabolic process
Response to hypoxia
Response to nutrient
S-adenosylhomocysteine catabolic process
S-adenosylmethionine cycle
Sulfur amino acid metabolic process

Cellular Location

Cytoplasm; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Involvement in disease

Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD): A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.

Gupta, A., & Storey, K. B. (2021). Coordinated expression of Jumonji and AHCY under OCT transcription factor control to regulate gene methylation in wood frogs during anoxia. Gene, 788, 145671.

Vizán, P., Di Croce, L., & Aranda, S. (2021). Functional and pathological roles of AHCY. Frontiers in Cell and Developmental Biology, 9, 587.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

AHCY Matched Antibody Pair (033) (CAT#: APMAB-033LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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