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AHSA1

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).

Full Name

Activator Of HSP90 ATPase Activity 1

Function

Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155).

Biological Process

Positive regulation of ATPase activity
Protein folding
Viral process

Cellular Location

Cytosol; Endoplasmic reticulum. May transiently interact with the endoplasmic reticulum.

PTM

Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.

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Anti-AHSA1 antibodies

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Rat Anti-AHSA1 Recombinant Antibody (V2-634176) (CBMAB-AP211LY)

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Target: AHSA1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: V2-634176

Application*: ICC/IF, ELISA, IHC, IP, WB

Mouse Anti-AHSA1 Recombinant Antibody (V2-634175) (CBMAB-AP210LY)

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Target: AHSA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: V2-634175

Application*: ICC/IF, ELISA, WB

Rat Anti-AHSA1 Recombinant Antibody (V2-634174) (CBMAB-AP209LY)

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Target: AHSA1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: V2-634174

Application*: ICC/IF, ELISA, IHC, IP, WB

Mouse Anti-AHSA1 Recombinant Antibody (V2-611053) (CBMAB-A0206-LY)

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Target: AHSA1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-611053

Application*: WB, E

Mouse Ahsa1 ELISA Kit (V2LY-0626-LY1983)

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Target: Ahsa1

Sensitivity: 0.0095 ng/mL

Detection Range: 0.02-3.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

AHSA1 Matched Antibody Pair (037) (APMAB-037LY)

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Target: AHSA1

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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