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APPBP2

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Full Name

Amyloid Beta Precursor Protein Binding Protein 2

Function

May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.

Biological Process

Intracellular protein transport Source: ProtInc
Intracellular transport Source: MGI

Cellular Location

Cytoskeleton; Nucleus; Membrane. Associated with membranes and microtubules.

PTM

Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

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Anti-APPBP2 antibodies

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Mouse Anti-Appbp2 Recombinant Antibody (CBYC-P019) (CBMAB-P0069-YC)

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Target: Appbp2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-P019

Application*: WB, E, IP

Mouse Anti-APPBP2 Recombinant Antibody (CBYC-A714) (CBMAB-A3333-YC)

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Target: APPBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-A714

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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