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APPBP2

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Full Name
Amyloid Beta Precursor Protein Binding Protein 2
Function
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
Biological Process
Intracellular protein transport Source: ProtInc
Intracellular transport Source: MGI
Cellular Location
Cytoskeleton; Nucleus; Membrane. Associated with membranes and microtubules.
PTM
Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.

Anti-APPBP2 antibodies

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Target: Appbp2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-P019
Application*: WB, E, IP
Target: APPBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-A714
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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