Atg4b

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Full Name
Autophagy Related 4B Cysteine Peptidase
Function
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Biological Process
Autophagy Source: BHF-UCL
Macroautophagy Source: Reactome
Positive regulation of protein catabolic process Source: Ensembl
Protein delipidation Source: MGI
Protein transport Source: UniProtKB-KW
Proteolysis Source: UniProtKB
Cellular Location
Cytoplasm
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Anti-Atg4b antibodies

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Mouse Anti-ATG4B Recombinant Antibody (CBYC-A856) (CBMAB-A3931-YC)

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Target: ATG4B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYC-A856
Application*: WB, IP
Datasheet SDS

Rabbit Anti-ATG4B Recombinant Antibody (CBYC-A855) (CBMAB-A3930-YC)

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Target: ATG4B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYC-A855
Application*: WB, FC
Datasheet SDS

Mouse Anti-ATG4B Recombinant Antibody (21.1.7) (CBMAB-A3929-YC)

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Target: ATG4B
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 21.1.7
Application*: WB
Datasheet SDS

Rabbit Anti-ATG4B Recombinant Antibody (1HCLC) (CBMAB-A3928-YC)

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Target: ATG4B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1HCLC
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-ATG4B Recombinant Antibody (CBT3454) (V2LY-0625-LY1291)

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Target: ATG4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3454
Application*: WB, F
Datasheet SDS

Mouse Anti-ATG4B Recombinant Antibody (CBT2850) (V2LY-0625-LY1290)

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Target: ATG4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2850
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-ATG4B Recombinant Antibody (EG293) (CBMAB-EN322-LY)

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Target: ATG4B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: EG293
Application*: WB, P, IF
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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