Bag5

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

BCL2 Associated Athanogene 5

Function

Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity).
May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Biological Process

Golgi organization Source: ParkinsonsUK-UCL
Negative regulation of neuron projection development Source: ParkinsonsUK-UCL
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
Negative regulation of protein refolding Source: BHF-UCL
Negative regulation of protein ubiquitination Source: ARUK-UCL
Negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
Neuron death Source: BHF-UCL
Protein folding Source: ProtInc
Protein stabilization Source: ARUK-UCL
Regulation of cellular response to heat Source: Reactome
Regulation of inclusion body assembly Source: BHF-UCL
Regulation of ubiquitin-protein transferase activity Source: ParkinsonsUK-UCL

Cellular Location

Cytosol; Mitochondrion; Nucleus; Cytoplasm; Inclusion body; Membrane; Perinuclear region of cytoplasm