BATF

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

Full Name

Basic Leucine Zipper ATF-Like Transcription Factor

Function

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8+ dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8+ dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8+ T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Defense response to protozoan Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Hematopoietic stem cell differentiation Source: UniProtKB
Isotype switching Source: UniProtKB
Lymphoid progenitor cell differentiation Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
T-helper 17 cell differentiation Source: UniProtKB
T-helper 17 cell lineage commitment Source: UniProtKB
T-helper 2 cell differentiation Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus. Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells.

PTM

Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).
Phosphorylated.