BCAS3

Full Name

breast carcinoma amplified sequence 3

Function

Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity).
Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy (PubMed:33499712).
Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures (PubMed:33499712).

Biological Process

Activation of GTPase activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cellular response to estrogen stimulus Source: UniProtKB
Golgi organization Source: UniProtKB
Microtubule organizing center organization Source: UniProtKB
Negative regulation of focal adhesion assembly Source: UniProtKB
Negative regulation of GTPase activity Source: UniProtKB
Positive regulation of actin cytoskeleton reorganization Source: UniProtKB
Positive regulation of catalytic activity Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of intracellular protein transport Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of establishment of cell polarity Source: UniProtKB
Response to starvation Source: GO_Central
Tube formation Source: UniProtKB

Cellular Location

Cytoplasm; Cytoskeleton; Nucleus; Preautophagosomal structure. Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712).