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BEST3

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).

Full Name

Bestrophin 3

Function

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Biological Process

Chloride transport Source: UniProtKB-KW
Negative regulation of ion transport Source: Ensembl

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-25 aa
Helical: 26-46 aa
Extracellular: 47-70 aa
Helical: 71-91 aa
Cytoplasmic: 92-178 aa
Helical: 179-199 aa
Extracellular: 200-228 aa
Intramembrane: 229-249 aa
Extracellular: 250-270 aa
Helical: 271-291 aa
Cytoplasmic: 292-668 aa

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Anti-BEST3 antibodies

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Mouse Anti-BEST3 Recombinant Antibody (CBYY-2049) (CBMAB-2398-YY)

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Target: BEST3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYY-2049

Application*: WB, IF, FC

Mouse Anti-BEST3 Recombinant Antibody (CBYY-2027) (CBMAB-2376-YY)

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Target: BEST3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYY-2027

Application*: FC, IF, WB

Mouse Anti-BEST3 Recombinant Antibody (CBYY-2004) (CBMAB-2353-YY)

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Target: BEST3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYY-2004

Application*: WB, IF, FC

Mouse Anti-BEST3 Recombinant Antibody (CBYY-1896) (CBMAB-2245-YY)

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Target: BEST3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBYY-1896

Application*: WB, IF, FC

Mouse Anti-BEST3 Recombinant Antibody (CBYY-0502) (CBMAB-0505-YY)

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Target: BEST3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYY-0502

Application*: WB, IF, FC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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