BEST3

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).
Full Name
Bestrophin 3
Function
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Biological Process
Chloride transport Source: UniProtKB-KW
Negative regulation of ion transport Source: Ensembl
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-25 aa
Helical: 26-46 aa
Extracellular: 47-70 aa
Helical: 71-91 aa
Cytoplasmic: 92-178 aa
Helical: 179-199 aa
Extracellular: 200-228 aa
Intramembrane: 229-249 aa
Extracellular: 250-270 aa
Helical: 271-291 aa
Cytoplasmic: 292-668 aa
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Anti-BEST3 antibodies

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Mouse Anti-BEST3 Recombinant Antibody (CBYY-2049) (CBMAB-2398-YY)

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Target: BEST3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYY-2049
Application*: WB, IF, FC
Mouse Anti-BEST3 Recombinant Antibody (CBYY-2049)
Datasheet SDS

Mouse Anti-BEST3 Recombinant Antibody (CBYY-2027) (CBMAB-2376-YY)

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Target: BEST3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBYY-2027
Application*: FC, IF, WB
Mouse Anti-BEST3 Recombinant Antibody (CBYY-2027)
Datasheet SDS

Mouse Anti-BEST3 Recombinant Antibody (CBYY-2004) (CBMAB-2353-YY)

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Target: BEST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-2004
Application*: WB, IF, FC
Mouse Anti-BEST3 Recombinant Antibody (CBYY-2004)
Datasheet SDS

Mouse Anti-BEST3 Recombinant Antibody (CBYY-1896) (CBMAB-2245-YY)

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Target: BEST3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBYY-1896
Application*: WB, IF, FC
Mouse Anti-BEST3 Recombinant Antibody (CBYY-1896)
Datasheet SDS

Mouse Anti-BEST3 Recombinant Antibody (CBYY-0502) (CBMAB-0505-YY)

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Target: BEST3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-0502
Application*: WB, IF, FC
Mouse Anti-BEST3 Recombinant Antibody (CBYY-0502)
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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