C1QTNF4

C1QTNF4 (C1q And TNF Related 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is C1QTNF8.

C1q And TNF Related 4

May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950).
Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).

Positive regulation of interleukin-6-mediated signaling pathway Source: UniProtKB
Positive regulation of interleukin-6 production Source: UniProtKB
Positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB

Secreted