C4BPB

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq]
Full Name
C4BPB
Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Biological Process
Blood coagulation Source: ProtInc
Complement activation, classical pathway Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Negative regulation of complement activation, classical pathway Source: BHF-UCL
Positive regulation of protein catabolic process Source: BHF-UCL
Regulation of complement activation Source: Reactome
Regulation of opsonization Source: BHF-UCL
Response to symbiotic bacterium Source: BHF-UCL
Cellular Location
Secreted
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Anti-C4BPB antibodies

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Rabbit Anti-C4BPB Recombinant Antibody (CBLC022-LY) (CBMAB-C9546-LY)

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Target: C4BPB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBLC022-LY
Application*: IP, IF, IH, IC, WB
Datasheet SDS

C4BPB Matched Antibody Pair (160) (APMAB-160LY)

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Target: C4BPB
Specificity: Human
Datasheet SDS

C4BPB Matched Antibody Pair (159) (APMAB-159LY)

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Target: C4BPB
Specificity: Human
Datasheet SDS

C4BPB Matched Antibody Pair (158) (APMAB-158LY)

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Target: C4BPB
Specificity: Human
Datasheet SDS

Mouse Anti-C4BPB Recombinant Antibody (CBXC-0019) (CBMAB-C5935-CQ)

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Target: C4BPB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0019
Application*: E, IP, WB
Datasheet SDS

Rabbit Anti-C4BPB Recombinant Antibody (CBXC-0018) (CBMAB-C5934-CQ)

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Target: C4BPB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXC-0018
Application*: IP, IF, IH, IC, WB
Datasheet SDS

Mouse Anti-C4BPB Recombinant Antibody (CBFYC-0648) (CBMAB-C0702-FY)

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Target: C4BPB
Host: Mouse
Antibody Isotype: IgG2b, ĸ
Specificity: Human
Clone: CBFYC-0648
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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