CA14

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.

carbonic anhydrase 14

Reversible hydration of carbon dioxide.

Bicarbonate transport Source: Reactome
One-carbon metabolic process Source: GO_Central

Membrane

Extracellular: 16-290 aa
Helical: 291-311 aa
Cytoplasmic: 312-337 aa