Sign in or Register

Keywords Search | Target Search

CASP9

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Full Name

Caspase 9

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Reactome
Apoptotic process Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to UV Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
Intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
Platelet formation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Regulation of response to DNA damage stimulus Source: UniProtKB
Signal transduction in response to DNA damage Source: UniProtKB

Cellular Location

Apoptosome; Cytosol; Cytoplasm; Protein-containing complex

PTM

Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.

Anti-CASP9 antibodies

Mouse Anti-CASP9 Recombinant Antibody (CBFYA-0233) (CBMAB-X0341-FY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYA-0233

Application*: IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CBXC-2486) (CBMAB-C5159-CQ)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBXC-2486

Application*: E, IF, IH, IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CBXC-0086) (CBMAB-C5158-CQ)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXC-0086

Application*: IH, WB

Mouse Anti-CASP9 Recombinant Antibody (CBFYC-0862) (CBMAB-C0917-FY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYC-0862

Application*: IH, IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CBFYC-0861) (CBMAB-C0916-FY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0861

Application*: P, IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CBFYC-0860) (CBMAB-C0915-FY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-0860

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (LAP6 96-2-22) (CBMAB-0169CQ)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: LAP6 96-2-22

Application*: IF, P, WB

Mouse Anti-CASP9 Recombinant Antibody (BA0430) (CBMAB-0168CQ)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: BA0430

Application*: WB, IF, IP

Mouse Anti-CASP9 Recombinant Antibody (EG489) (CBMAB-EN554-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse

Clone: EG489

Application*: WB: 1:1, 000-5, 000 IP:1:200

Rabbit Anti-CASP9 Recombinant Antibody (EG488) (CBMAB-EN553-LY)

SDS

Target: CASP9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG488

Application*: WB: 1:500~1:1000 ELISA: 1:5000

Mouse Anti-CASP9 Recombinant Antibody (34) (CBMAB-AP816LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 34

Application*: ELISA, IF, IHC, WB

Mouse Anti-CASP9 Recombinant Antibody (CAP323) (CBMAB-AP814LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP323

Application*: IP, WB

Rabbit Anti-CASP9 Recombinant Antibody (CAP322) (CBMAB-AP813LY)

SDS

Target: CASP9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CAP322

Application*: ICC, IF, IHC, IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CAP321) (CBMAB-AP812LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP321

Application*: IHC, WB

Mouse Anti-CASP9 Recombinant Antibody (CAP320) (CBMAB-AP811LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP320

Application*: ELISA, IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CF063) (CBMAB-FT409LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CF063

Application*: ELISA, WB, IHC

Mouse Anti-CASP9 Recombinant Antibody (CB12A) (CBMAB-CA012LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB12A

Application*: ELISA, WB, IP

Mouse Anti-CASP9 Recombinant Antibody (CB033) (CBMAB-CS033LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CB033

Application*: WB, IF/ICC, IP

Recombinant Mouse Anti-CASP9 Antibody (CBHb349) (CBMAB-Hb211-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBHb349

Application*: IP, WB

Recombinant Mouse Anti-CASP9Antibody (CBAb046) (CBMAB-Ab046-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb046

Application*: WB, IH

Recombinant Rabbit Anti-CASP9Antibody (CBAb045) (CBMAB-Ab045-LY)

SDS

Target: CASP9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBAb045

Application*: WB, IH, IC, IF, IP

Mouse Anti-CASP9 Recombinant Antibody (CBLC118-LY) (CBMAB-C9750-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLC118-LY

Application*: E, WB

Mouse Anti-CASP9 Recombinant Antibody (2-22) (CBMAB-C0669-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2-22

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (01-02-22) (CBMAB-C1595-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 01-02-22

Application*: P, WB

Mouse Anti-CASP9 Recombinant Antibody (10-1-87) (CBMAB-C2036-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 10-1-87

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (14i12) (CBMAB-C3046-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 14i12

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (1D1-F2-E9) (CBMAB-C3814-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D1-F2-E9

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (31787) (CBMAB-C5485-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 31787

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (3-20) (CBMAB-C5494-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3-20

Application*: IP, WB

Mouse Anti-CASP9 Recombinant Antibody (32051) (CBMAB-C5495-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 32051

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (3B8-4G2) (CBMAB-C5756-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3B8-4G2

Application*: E, IF, WB

Mouse Anti-CASP9 Recombinant Antibody (3C122) (CBMAB-C5796-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3C122

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (3I3) (CBMAB-C6384-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 3I3

Application*: WB, IP

Mouse Anti-CASP9 Recombinant Antibody (42788) (CBMAB-C6474-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 42788

Application*: WB, IH, IP, P

Mouse Anti-CASP9 Recombinant Antibody (44593) (CBMAB-C6495-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 44593

Application*: WB, IP, P

Mouse Anti-CASP9 Recombinant Antibody (4F12-G6) (CBMAB-C6918-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4F12-G6

Application*: E, PL, WB

Mouse Anti-CASP9 Recombinant Antibody (4i14) (CBMAB-C7089-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4i14

Application*: E, WB

Mouse Anti-CASP9 Recombinant Antibody (5B4) (CBMAB-C7321-LY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: 5B4

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (96-2-22) (CBMAB-C2165-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 96-2-22

Application*: IP, WB

Mouse Anti-CASP9 Recombinant Antibody (CBYY-C0990) (CBMAB-C2427-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C0990

Application*: WB

Mouse Anti-CASP9 Recombinant Antibody (CBYY-C0991) (CBMAB-C2428-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C0991

Application*: E, IF, WB

Mouse Anti-CASP9 Recombinant Antibody (CBYY-C0992) (CBMAB-C2429-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYY-C0992

Application*: WB, IP

Mouse Anti-CASP9 Recombinant Antibody (CBYY-C0993) (CBMAB-C2430-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C0993

Application*: WB, IH, IP, P

Mouse Anti-CASP9 (AA 2-22) Recombinant Antibody (CBYY-C0994) (CBMAB-C2431-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: CBYY-C0994

Application*: WB, IP, P

Mouse Anti-CASP9 (N-terminus) Recombinant Antibody (CBYY-C0996) (CBMAB-C2433-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-C0996

Application*: E, WB

Mouse Anti-CASP9 Recombinant Antibody (CBYY-C0998) (CBMAB-C2435-YY)

SDS

Target: CASP9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C0998

Application*: E, IP, WB

Rabbit Anti-CASP9 Recombinant Antibody (CBNH-014) (CBMAB-R4339-CN)

SDS

Target: CASP9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBNH-014

Application*: E, WB, IF, F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Go to
Compare