CASP9

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Full Name
Caspase 9
Alternative Names
CASP9; APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56; caspase-9
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Reactome
Apoptotic process Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to UV Source: UniProtKB
Extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
Intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
Platelet formation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Regulation of response to DNA damage stimulus Source: UniProtKB
Signal transduction in response to DNA damage Source: UniProtKB
Cellular Location
Apoptosome; Cytosol; Cytoplasm; Protein-containing complex
PTM
Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.
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Anti-CASP9 antibodies

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Rabbit Anti-CASP9 Recombinant Antibody (CBAb045) (CBMAB-Ab045-LY)

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Target: CASP9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBAb045
Application*: WB, IH, IC, IF, IP
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (CBFYC-0860) (CBMAB-C0915-FY)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0860
Application*: E, P, IF, IP, WB
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (4i14) (CBMAB-C7089-LY)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4i14
Application*: WB, IP
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (4F12-G6) (CBMAB-C6918-LY)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F12-G6
Application*: E, WB
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (3B8-4G2) (CBMAB-C5756-LY)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B8-4G2
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (CBT14) (V2LY-0625-LY3869)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, chicken
Clone: CBT14
Application*: WB, P, IF, IC, IP
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (CBT4045) (V2LY-0625-LY1294)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4045
Application*: F
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (EC95) (V2LY-0624-LY95)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EC95
Application*: WB, P, IF, IP
Datasheet SDS

Rabbit Anti-CASP9 Recombinant Antibody (CBNH-014) (CBMAB-R4339-CN)

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Target: CASP9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-014
Application*: E, WB, IF, F
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (LAP6 96-2-22) (CBMAB-0169CQ)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: LAP6 96-2-22
Application*: IP, WB, E
Datasheet SDS

Mouse Anti-CASP9 Recombinant Antibody (BA0430) (CBMAB-0168CQ)

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Target: CASP9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: BA0430
Application*: IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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