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CCL2

CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are Ectoderm Differentiation and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase activity and heparin binding. An important paralog of this gene is CCL7.
Full Name
C-C Motif Chemokine Ligand 2
Function
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171).
Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439).
Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247).
May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690).
Biological Process
Angiogenesis Source: BHF-UCL
Animal organ morphogenesis Source: ProtInc
Astrocyte cell migration Source: BHF-UCL
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Cellular homeostasis Source: BHF-UCL
Cellular response to fibroblast growth factor stimulus Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to lipopolysaccharide Source: BHF-UCL
Cellular response to organic cyclic compound Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: BHF-UCL
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Helper T cell extravasation Source: BHF-UCL
Humoral immune response Source: ProtInc
Inflammatory response Source: UniProtKB
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Macrophage chemotaxis Source: BHF-UCL
MAPK cascade Source: UniProtKB
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Negative regulation of glial cell apoptotic process Source: UniProtKB
Negative regulation of natural killer cell chemotaxis Source: UniProtKB
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of vascular endothelial cell proliferation Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
PERK-mediated unfolded protein response Source: Reactome
Positive regulation of apoptotic cell clearance Source: BHF-UCL
Positive regulation of calcium ion import Source: BHF-UCL
Positive regulation of endothelial cell apoptotic process Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Positive regulation of NMDA glutamate receptor activity Source: ARUK-UCL
Positive regulation of synaptic transmission, glutamatergic Source: UniProtKB
Positive regulation of T cell activation Source: BHF-UCL
Protein kinase B signaling Source: UniProtKB
Protein phosphorylation Source: ProtInc
Receptor signaling pathway via JAK-STAT Source: ProtInc
Regulation of cell shape Source: UniProtKB
Response to bacterium Source: BHF-UCL
Sensory perception of pain Source: UniProtKB
Signal transduction Source: ProtInc
Viral genome replication Source: ProtInc
Cellular Location
Secreted
PTM
Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182).
N-Glycosylated.

Anti-CCL2 antibodies

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Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A023
Application*: Sandwich ELISA, WB, IHC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: A022
Application*: ELISA, IHC, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP360
Application*: Dot blot, ELISA
Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP359
Application*: Dot blot, ELISA
Target: CCL2
Host: Rat
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP358
Application*: Dot blot, ELISA
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CAP357
Application*: ELISA, IHC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0154
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: CBFYA-0076
Application*: F, C, FN, IA, IP, P, WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: ECE.2
Application*: C, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0114
Application*: WB, SE, E
Target: CCL2
Host: Hamster
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXC-2141
Application*: F, FN, N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2711
Application*: E, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-0116
Application*: E, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0115
Application*: E, N, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2677
Application*: E, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1025
Application*: IH
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S14
Application*: E, N, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2014
Application*: WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXC-0963
Application*: N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MNA1
Application*: IC, C, N, WB
Target: CCL2
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-0861
Application*: F
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1026
Application*: WB, N, EC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXC-2088
Application*: WB, F, E, IH, IF, P
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2475
Application*: WB, E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0953
Application*: ED, E, P
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0952
Application*: E, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0951
Application*: WB, N, EC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0950
Application*: IH
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBFYC-0949
Application*: E, IC, N, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0471
Application*: WB, N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0363
Application*: E, WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYC-0243
Application*: F
Target: CCL2
Host: Mouse
Specificity: Rabbit
Clone: CBFYM-0919
Application*: E, IC, IH, WB
Target: CCL2
Host: Human
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBFYM-0918
Application*: F, IA, P, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBFYM-0917
Application*: E, WB, P, IF, F
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0916
Application*: ED, N, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0915
Application*: WB, IC, C, P, E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0914
Application*: E, IP, N, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0913
Application*: E, IC, IH, IP, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYM-0779
Application*: EC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Human
Clone: CBFYM-0406
Application*: WB, E, N
Target: CCL2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBFYM-0272
Application*: E, IH, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0267
Application*: E, WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-0194
Application*: E, IH, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0178
Application*: EC, BL, F, N
Target: CCL2
Host: Armenian Hamster
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBFYM-0119
Application*: E, F, N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0045
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0153
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0152
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0151
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0150
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0149
Application*: WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB325A
Application*: ELISA, IHC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A7B8
Application*: ELISA, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: CBHb121
Application*: FC, IHC-F, FuncS, Immuno assays, IP, IHC-P, WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBHb013
Application*: IHC-F, WB
Target: CCL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: E9R7Z
Application*: WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E10
Application*: WB, E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rabbit, Rat
Clone: 1B9F7
Application*: E, IH, WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0172-11K27
Application*: WB, B/N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: YNR-HMCAF
Application*: E, IP, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S8
Application*: E, N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: MB10
Application*: IH, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: S382
Application*: IA, FN
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: S101
Application*: IA
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D2E5
Application*: E, IH
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L97
Application*: IH, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: 13B102
Application*: E, FC, IH, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1071
Application*: IH
Target: CCL2
Host: Hamster
Specificity: Mouse
Clone: CBYY-C1069
Application*: E
Target: CCL2
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-C0275
Application*: E(Det), ES
Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rabbit
Clone: CBLC-LY-005
Application*: E, WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5J.1
Application*: C
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5D3-F7
Application*: E, F, P, IP
Target: CCL2
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 4E2/MCP
Application*: E, ELISpot
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: 280702
Application*: WB, N, IC, EC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 23007
Application*: WB, N, EC
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2-2-4A4-1A11
Application*: ED, IA, P
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F10
Application*: E, WB
Target: CCL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 11K27
Application*: WB, N
Target: CCL2
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 4E2
Application*: E
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 2D8
Application*: WB, F, E, IH, IC/IF, P
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Dog
Clone: 280707
Application*: WB
Target: CCL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24822
Application*: WB, N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 23002
Application*: IH
Target: CCL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 123616R
Application*: F
Target: CCL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 123616
Application*: N
Target: CCL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG510
Application*: ELISA, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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