CCR3

CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Folliculotropic Mycosis Fungoides and Aids Dementia Complex. Among its related pathways are Akt Signaling and IL1 and megakaryocytes in obesity. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR1.
Full Name
C-C Motif Chemokine Receptor 3
Function
Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064).
Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064).
In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of endothelial cell proliferation Source: Ensembl
Viral process Source: UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 1-34
Helical: 35-62
Cytoplasmic: 63-72
Helical: 73-93
Extracellular: 94-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-203
Helical: 204-223
Cytoplasmic: 224-239
Helical: 240-264
Extracellular: 265-281
Helical: 282-305
Cytoplasmic: 306-355
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Anti-CCR3 antibodies

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Rat Anti-CCR3 Recombinant Antibody (CBYY-C0675) (CBMAB-C1997-YY)

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Target: CCR3
Host: Rat
Antibody Isotype: IgG2b, λ
Specificity: Mouse
Clone: CBYY-C0675
Application*: In vivo
In Vivo Assay
Datasheet SDS

Rabbit Anti-CCR3 Recombinant Antibody (CBFYC-1074) (CBMAB-C1131-FY)

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Target: CCR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYC-1074
Application*: IC, IF, WB, IH
Datasheet SDS

Rat Anti-CCR3 Recombinant Antibody (83103) (CBMAB-C8962-LY)

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Target: CCR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 83103
Application*: F
Datasheet SDS

Rat Anti-CCR3 Recombinant Antibody (61828) (CBMAB-C7875-LY)

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Target: CCR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 61828
Application*: F, IH, N
Functional Assay
Datasheet SDS

Mouse Anti-CCR3 Recombinant Antibody (5E8-G9-B4) (CBMAB-C7524-LY)

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Target: CCR3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E8-G9-B4
Application*: F
Datasheet SDS

Mouse Anti-CCR3 Recombinant Antibody (5E8) (CBMAB-C7516-LY)

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Target: CCR3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5E8
Application*: WB, IP, F
Datasheet SDS

Human CCR3 ELISA Kit (V2LY-0626-LY4368)

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Target: CCR3
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-CCR3 Recombinant Antibody (CBT3018) (V2LY-0625-LY773)

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Target: CCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3018
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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