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CCR3

CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include Folliculotropic Mycosis Fungoides and Aids Dementia Complex. Among its related pathways are Akt Signaling and IL1 and megakaryocytes in obesity. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR1.

Full Name

C-C Motif Chemokine Receptor 3

Function

Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064).
Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064).
In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Biological Process

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of endothelial cell proliferation Source: Ensembl
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 1-34
Helical: 35-62
Cytoplasmic: 63-72
Helical: 73-93
Extracellular: 94-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-203
Helical: 204-223
Cytoplasmic: 224-239
Helical: 240-264
Extracellular: 265-281
Helical: 282-305
Cytoplasmic: 306-355

Anti-CCR3 antibodies

Human Anti-CCR3 Recombinant Antibody (CBXC-0883) (CBMAB-C1998-CQ)

SDS

Target: CCR3

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0883

Application*: F

Mouse Anti-CCR3 Recombinant Antibody (CBXC-2941) (CBMAB-C1687-CQ)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-2941

Application*: F

Rat Anti-CCR3 Recombinant Antibody (CBXC-1263) (CBMAB-C1530-CQ)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-1263

Application*: F

Rat Anti-CCR3 Recombinant Antibody (CBXC-3055) (CBMAB-C0891-CQ)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXC-3055

Application*: F, IH, P

Mouse Anti-CCR3 Recombinant Antibody (CBXC-2942) (CBMAB-C0288-CQ)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-2942

Application*: F

Rabbit Anti-CCR3 (AA 172-190) Recombinant Antibody (CBFYC-1074) (CBMAB-C1131-FY)

SDS

Target: CCR3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-1074

Application*: IC, IF

Mouse Anti-CCR3 Recombinant Antibody (CBFYC-1073) (CBMAB-C1130-FY)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBFYC-1073

Application*: C, F

Rat Anti-CCR3 Recombinant Antibody (83103) (CBMAB-C8962-LY)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 83103

Application*: F, MC

Rat Anti-CCR3 Recombinant Antibody (RM0186-36C4) (CBMAB-C9930-LY)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: RM0186-36C4

Application*: F

Rat Anti-CCR3 Recombinant Antibody (MM0063-7F12) (CBMAB-C9929-LY)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0063-7F12

Application*: F

Rabbit Anti-CCR3 Recombinant Antibody (Y31) (CBMAB-C9931-LY)

SDS

Target: CCR3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: Y31

Application*: WB, P, IC, IC/IF

Mouse Anti-CCR3 Recombinant Antibody (6D240) (CBMAB-C1490-CN)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6D240

Application*: FC

Rabbit Anti-CCR3 Recombinant Antibody (14L129) (CBMAB-C1487-CN)

SDS

Target: CCR3

Host: Rabbit

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L129

Application*: FC, IH

Rabbit Anti-CCR3 Recombinant Antibody (11n21) (CBMAB-C1486-CN)

SDS

Target: CCR3

Host: Rabbit

Antibody Isotype: IgG2a

Specificity: Human

Clone: 11n21

Application*: E

Rat Anti-CCR3 Recombinant Antibody (CBYY-C0675) (CBMAB-C1997-YY)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYY-C0675

Application*: F

Mouse Anti-CCR3 Recombinant Antibody (CBYY-C0365) (CBMAB-C1264-YY)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-C0365

Application*: F

Mouse Anti-CCR3 Recombinant Antibody (500000000) (CBMAB-C1013-YY)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 500000000

Application*: C, F, IF

Rat Anti-CCR3 Recombinant Antibody (7F12) (CBMAB-C8691-LY)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG

Specificity: Human

Clone: 7F12

Application*: F, IH

Rat Anti-CCR3 Recombinant Antibody (61828) (CBMAB-C7875-LY)

SDS

Target: CCR3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: 61828

Application*: F, IH, N, MC

Mouse Anti-CCR3 Recombinant Antibody (5E8-G9-B4) (CBMAB-C7524-LY)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 5E8-G9-B4

Application*: F

Mouse Anti-CCR3 Recombinant Antibody (5E8) (CBMAB-C7516-LY)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5E8

Application*: C, F, IC/IF

Rabbit Anti-CCR3 Recombinant Antibody (23H17L1) (CBMAB-C4461-LY)

SDS

Target: CCR3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 23H17L1

Application*: IC, IF

Mouse Anti-CCR3 Recombinant Antibody (444-11) (CBMAB-C1302-LY)

SDS

Target: CCR3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 444-11

Application*: F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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