CD209b

We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells.
Full Name
CD209b antigen
Alternative Names
1810030I22Rik; DC-SIGNR1; OtB7; SIGNR1; mSIGNR1
Function
Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
Biological Process
Detection of bacterium Source: MGI
Detection of yeast Source: MGI
Endocytosis Source: MGI
Phagocytosis, recognition Source: MGI
Positive regulation of phagocytosis Source: MGI
Positive regulation of tumor necrosis factor production Source: MGI
Cellular Location
Membrane
Topology
Cytoplasmic: 1-52
Helical: 53-73
Extracellular: 74-325
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Anti-CD209b antibodies

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Target: CD209b
Host: Armenian Hamster
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: AG12
Application*: B, F, C, WB
Functional Assay
Target: CD209B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 74-325
Tag: His Tag
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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