CD320

CD320 (CD320 Molecule) is a Protein Coding gene. Diseases associated with CD320 include Methylmalonic Aciduria, Transient, Due To Transcobalamin Receptor Defect and Methylmalonic Acidemia Due To Transcobalamin Receptor Defect. Among its related pathways are Diseases of metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include growth factor activity and cobalamin binding.

Full Name

CD320 molecule

Function

Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389).
Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213).
Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470).
Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631).
Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631).
CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631).

Biological Process

B cell costimulation Source: UniProtKB
Cobalamin metabolic process Source: Reactome
Cobalamin transport Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Methylmalonic aciduria, transient, due to transcobalamin receptor defect (MMATC): A metabolic disorder characterized by increased blood C3-acylcarnitine levels, elevated methylmalonate and homocysteine, and low uptake of transcobalamin-bound cobalamin, but normal conversion to adenosylcobalamin and methylcobalamin.

Topology

Extracellular: 36-229
Helical: 230-250
Cytoplasmic: 251-282