CIRBP

CIRBP (Cold Inducible RNA Binding Protein) is a Protein Coding gene. Diseases associated with CIRBP include Cryptorchidism, Unilateral Or Bilateral. Among its related pathways are DNA Damage and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMX.
Full Name
Cold Inducible RNA Binding Protein
Function
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity).

Promotes assembly of stress granules (SGs), when overexpressed.
Biological Process
mRNA stabilization Source: UniProtKB
Positive regulation of mRNA splicing, via spliceosome Source: GO_Central
Positive regulation of translation Source: UniProtKB
Response to cold Source: ProtInc
Response to UV Source: UniProtKB
Stress granule assembly Source: UniProtKB
Cellular Location
Cytoplasm; Nucleoplasm. Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
PTM
Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.
View more

Anti-CIRBP antibodies

+ Filters
Loading...

Rabbit Anti-CIRBP Recombinant Antibody (CP0315) (CBMAB-CP0315-LY)

Go to compareCompare
Target: CIRBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CP0315
Application*: IP, IF, WB, IH
Datasheet SDS

Mouse Anti-CIRBP Recombinant Antibody (CBFYC-1876) (CBMAB-C1941-FY)

Go to compareCompare
Target: CIRBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1876
Application*: WB, E, P
Datasheet SDS

Mouse Anti-CIRBP Recombinant Antibody (1C9) (CBMAB-C3784-LY)

Go to compareCompare
Target: CIRBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 1C9
Application*: WB, IP, IF, E, P
Datasheet SDS

Human CIRBP ELISA Kit (2) (V2LY-0626-LY5740)

Go to compareCompare
Target: CIRBP
Sensitivity: 0.008 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human CIRBP ELISA Kit (V2LY-0626-LY4420)

Go to compareCompare
Target: CIRBP
Sensitivity: 0.004 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Cirbp ELISA Kit (V2LY-0626-LY2198)

Go to compareCompare
Target: Cirbp
Sensitivity: 0.0022 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rat Cirbp ELISA Kit (V2LY-0626-LY1570)

Go to compareCompare
Target: Cirbp
Sensitivity: 0.0025 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Mouse Anti-CIRBP Recombinant Antibody (CBT4787) (V2LY-0625-LY682)

Go to compareCompare
Target: CIRBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4787
Application*: IH
Datasheet SDS

Mouse Anti-CIRBP Recombinant Antibody (CBT2437) (V2LY-0625-LY658)

Go to compareCompare
Target: CIRBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2437
Application*: WB, IH
Datasheet SDS

CIRBP Matched Antibody Pair (271) (APMAB-271LY)

Go to compareCompare
Target: CIRBP
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.